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8-Oxoguanine DNA Glycosylase (OGG1) (Internal Region) antibody

Details for Product No. ABIN374768
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Antigen
Synonyms
OGG1, zgc:158858, 8-oxoguanine-DNA glycosylase 1, ARABIDOPSIS 8-OXOGUANINE-DNA GLYCOSYLASE 1, ATOGG1, F8K7.14, F8K7_14, 19.m02329, DDBDRAFT_0184479, DDBDRAFT_0233024, DDB_0184479, DDB_0233024, ogg1, T ... show more
OGG1, zgc:158858, 8-oxoguanine-DNA glycosylase 1, ARABIDOPSIS 8-OXOGUANINE-DNA GLYCOSYLASE 1, ATOGG1, F8K7.14, F8K7_14, 19.m02329, DDBDRAFT_0184479, DDBDRAFT_0233024, DDB_0184479, DDB_0233024, ogg1, Tb04.1H19.930, HMMH, HOGG1, MUTM, OGH1, Mmh show less
Epitope
Internal Region
(11), (11), (3), (3), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus)
(56), (36), (31), (12), (12), (12), (6), (2), (1)
Host
Goat
(54), (6), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(53), (17), (15), (13), (10), (6), (4), (3), (3), (2), (1)
Pubmed 1 reference available
Quantity 0.1 mg
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Catalog No. ABIN374768
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Immunogen Peptide with sequence C-HPKTSQAKGPSPLANK, from the internal region of the protein sequence
Specificity This antibody reacts to OGG1. Species Reactivity: Tested: Rat. Expected from sequence similarity: Mouse.
Purification Affinity chromatography
Alternative Name OGG1
Background The Ogg1 gene encodes a DNA repair enzyme (N glycosylase/DNA lyase) that incises DNA at 8 oxoG residues. N glycosylase/DNA lyase excises 7,8 dihydro 8 oxoguanine and 2,6 diamino 4 hydroxy 5 N methylformamidopyrimidine (FAPY) from damaged DNA. N glycosylase/DNA lyase has a beta lyase activity that nicks DNA 3' to the lesion. Alternative splicing of the C terminal region of the Ogg1 gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N terminal region in common. Many alternative splice variants for this gene have been described, but the full length nature for every variant has not been determined. The N terminus of this gene contains a mitochondrial targetting signal, essential for mitochondrial localization.
Alternate names: MMH, MUTM, N-glycosylase/DNA lyase, OGH1
Gene ID 4968
NCBI Accession 9606
UniProt O15527
Application Notes Peptide ELISA: 1/128000. Western Blot: 0.1 - 0.3 µg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris buffered saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
anti-8-Oxoguanine DNA Glycosylase (OGG1) (Internal Region) antibody anti-8-Oxoguanine DNA Glycosylase (OGG1) (Internal Region) antibody
Background publications Kovtun, Liu, Bjoras et al.: "OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells." in: Nature, Vol. 447, Issue 7143, pp. 447-52, 2007 (PubMed).

Validation Images
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