OGG1 antibody (AA 151-250)

Catalog No. ABIN702655

Product Details anti-OGG1 Antibody

Target: OGG1 (8-Oxoguanine DNA Glycosylase (OGG1))

Binding Specificity: AA 151-250

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OGG1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human OGG1/8 hydroxyguanine DNA glycosylase

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-OGG1 antibody (ABIN702655)

Cogoi, Ferino, Miglietta, Pedersen, Xodo: "The regulatory G4 motif of the Kirsten ras (KRAS) gene is sensitive to guanine oxidation: implications on transcription." in: Nucleic acids research, Vol. 46, Issue 2, pp. 661-676, (2017) (PubMed).

Target Details for OGG1

Target: OGG1 (8-Oxoguanine DNA Glycosylase (OGG1))

Alternative Name: OGG1 (OGG1 Products)

Synonyms: OGG1 antibody, zgc:158858 antibody, 8-oxoguanine-DNA glycosylase 1 antibody, ARABIDOPSIS 8-OXOGUANINE-DNA GLYCOSYLASE 1 antibody, ATOGG1 antibody, F8K7.14 antibody, F8K7_14 antibody, 19.m02329 antibody, DDBDRAFT_0184479 antibody, DDBDRAFT_0233024 antibody, DDB_0184479 antibody, DDB_0233024 antibody, ogg1 antibody, Tb04.1H19.930 antibody, HMMH antibody, HOGG1 antibody, MUTM antibody, OGH1 antibody, Mmh antibody, 8-oxoguanine DNA glycosylase antibody, 8-oxoguanine DNA glycosylase L homeolog antibody, 8-oxoguanine-DNA glycosylase 1 antibody, 8-OXOGUANINE DNA GLYCOSYLASE antibody, putative 8-oxoguanine DNA glycosylase antibody, 8-oxoguanine DNA-glycosylase antibody, N-glycosylase/DNA lyase OGG1 antibody, 8-oxoguanine DNA-glycosylase 1 antibody, OGG1 antibody, ogg1.L antibody, ogg1 antibody, ECU08_0770 antibody, CA_C2707 antibody, BBOV_I004290 antibody, Smp_074010.1 antibody, LOC9329243 antibody, Tb927.4.2480 antibody, Ogg1 antibody

Background:

Synonyms: 8 hydroxyguanine DNA glycosylase, 8 oxoguanine DNA glycosylase 1, 8-oxoguanine DNA glycosylase, AP lyase, DNA apurinic or apyrimidinic site lyase, DNA lyase, DNA-apurinic or apyrimidinic site lyase, HMMH, HOGG 1, HOGG1, MMH, MUTM, N-glycosylase, Ogg 1, OGH 1, OGH1, OGG1_HUMAN.

Background: This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008].

Gene ID: 4968

Pathways: DNA Damage Repair