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Details for Product No. ABIN374821

Roundabout, Axon Guidance Receptor, Homolog 3 (Drosophila) (ROBO3) (Internal Region) antibody

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Antigen
Synonyms HGPPS, HGPS, RBIG1, RIG1, Rig1, Rbig1, Rig-1, Robo3a, Robo3b
Epitope
»Alternatives Internal Region
Reactivity
»Alternatives Human
Host
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN374821
Quantity 0.1 mg
Price
346.50 $   Plus shipping costs $45.00
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Immunogen Peptide with sequence from the internal region of the protein sequence Genename: ROBO3
Sequence C-RRKQRKELSHYT
Specificity This antibody detects ROBO3/RIG1 (internal). Species Reactivity: Tested: Human.
Purification Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.
Alternative Name ROBO3
Background Roundabout proteins 1-3, known as Robo1-3, are repulsive axon guidance receptors that bind to Slit, a repellent secreted by midline glia during development. Robo3 (also known as Rig1) is important for normal axon navigation at the ventral midline of the neural tube during development and is specifically expressed by commissural axons in rodents. Loss- of-function studies in mice show that Robo3 is required to allow commissural axons to enter the floor plate and cross to the contralateral side of the spinal cord. Some isoforms of Robo3 exist.
Alternate names: ROBO-3, Roundabout homolog 3, Roundabout-like protein 3
Molecular Weight 148kDa (NP_071765.2).
Gene ID 64221
NCBI Accession 9606
UniProt Q96MS0
Application Notes Peptide ELISA: 1/32000. Western Blot: 0.5 - 1 µg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris buffered saline, pH 7.3 containing 0.02% Sodium Azide as preservative and 0.5% BSA as stabilizer.
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Kato, Takeuchi, Sato et al.: "Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses." in: Nature, Vol. 441, Issue 7089, pp. 101-5, 2006 (PubMed).

Alternatives for antigen "Roundabout, Axon Guidance Receptor, Homolog 3 (Drosophila) (ROBO3)", type "Antibodies"
Hosts (22), (11), (5)
Reactivities (31), (23), (18), (18), (17), (17), (17)
Applications (18), (17), (15), (10), (5), (4), (4)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (5), (1), (1)
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