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ROBO3 Products

(Roundabout, Axon Guidance Receptor, Homolog 3 (ROBO3))

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This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS)\; an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. Alternative transcript variants have been described but have not been experimentally validated. [provided by RefSeq, Dec 2009].

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Featured ROBO3 Categories

ROBO3 Antibodies

High quality antibodies with extensive validation data.

ROBO3 ELISA Kits

Reliable ELISA kits for a wide range of species.

ROBO3 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended ROBO3 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (3)
Cat. No. ABIN528582
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (1)
  • (1)
Cat. No. ABIN190793
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (1)
Cat. No. ABIN7168446
Quantity 100 μL
Datasheet Datasheet

Recommended ROBO3 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN4884368
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6384942
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6730276
Quantity 96 tests
Datasheet Datasheet

Recommended ROBO3 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1318429
Quantity 10 μg
Datasheet Datasheet
Reactivity Cow, Human, Monkey, Panda
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN2751303
Quantity 5 applications
Datasheet Datasheet

Latest Publications for our ROBO3 products

Bauer, Dowejko, Bosserhoff, Reichert, Bauer: "Slit-2 facilitates interaction of P-cadherin with Robo-3 and inhibits cell migration in an oral squamous cell carcinoma cell line." in: Carcinogenesis, Vol. 32, Issue 6, pp. 935-43, (2011) (PubMed).

Kato, Takeuchi, Sato, Yoneyama, Yamamoto, Matsui, Uematsu, Jung, Kawai, Ishii, Yamaguchi, Otsu, Tsujimura, Koh, Reis e Sousa, Matsuura, Fujita, Akira: "Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses." in: Nature, Vol. 441, Issue 7089, pp. 101-5, (2006) (PubMed).

Synonyms and alternative names related to ROBO3

roundabout guidance receptor 3 (ROBO3), roundabout 3 (robo3), roundabout guidance receptor 3 (Robo3), robo3 (LOC658818), roundabout guidance receptor 3 L homeolog (robo3.L), roundabout, axon guidance receptor, homolog 3 (Drosophila) (robo3), cb503, CG5423, CG14345, CT17158, DKFZp468G0223, DmelCG5423, dRobo-3, HGPPS, HGPS, RBIG1, Rbig1, Rig-1, RIG1, Rig1, Robo-3, Robo3, ROBO3, robo3, Robo3a, Robo3b

Protein level used designations for ROBO3

  • retinoblastoma inhibiting gene 1
  • roundabout homolog 3
  • roundabout-like protein 3
  • robo3
  • CG5423-PA
  • robo3-PA
  • roundabout, axon guidance receptor, homolog 3
  • roundabout, axon guidance receptor, homolog 3 (Drosophila)
  • GLEAN_06743
  • roundabout 3
  • roundabout homolog 3-like
  • retinoblastoma-inhibiting gene 1 protein
  • roundabout (axon guidance receptor, Drosophila) homolog 3
  • twi
  • twitch twice
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