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Apolipoprotein A-V (APOA5) (C-Term) antibody

Details for Product No. ABIN375169, Supplier: Log in to see
Antigen
  • APOA5
  • MGC140487
  • rap3
  • apoav
  • apoa-v
  • APOAV
  • RAP3
  • apo-AV
  • apoA-V
  • 1300007O05Rik
  • Apoav
Epitope
C-Term
18
14
6
5
5
3
3
3
2
2
2
1
1
1
Reactivity
Human
137
24
20
7
1
1
1
Host
Goat
80
57
12
Clonality
Polyclonal
Conjugate
Un-conjugated
7
5
4
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
111
90
12
11
11
7
5
4
3
1
Supplier
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Immunogen Peptide with sequence C-HSLHDQGHSHLGDP, from the C Terminus of the protein sequence
Specificity This antibody reacts to APOA5.
Purification Affinity chromatography
Alternative Name Apolipoprotein A V (ApoA V) (APOA5 Antibody Abstract)
Background Apolipoprotein A V is a minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. It may also be associated with chylomicrons. It is an important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). Apolipoprotein A V activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Apolipoprotein A V is upregulated by PPARA agonists, which are used clinically to lower serum TG (such as fibrates). It is induced in early phase of liver regeneration. Defects in Apolipoprotein A V gene are a cause of susceptibility to familial hypertriglyceridemia. It is a coronary heart disease risk factor. On a regular diet the patient demonstrates increased plasma VLDL. Plasma triglycerides are persistently increased, while plasma cholesterol and phospholipids are usually within normal limits.Synonyms: APOA5, Apo-AV, ApoA-V, Apolipoprotein A-V, RAP3, Regeneration-associated protein 3
Gene ID 116519, 9606
UniProt Q6Q788
Research Area Metabolism
Pathways
Application Notes Peptide ELISA: 1/64000. Western Blot: 0.3 - 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0,5 mg/mL
Buffer Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-Apolipoprotein A-V (APOA5) (C-Term) antibody (ABIN375169) anti-Apolipoprotein A-V (APOA5) (C-Term) antibody
Background publications Corella, Lai, Demissie et al.: "APOA5 gene variation modulates the effects of dietary fat intake on body mass index and obesity risk in the Framingham Heart Study." in: Journal of molecular medicine (Berlin, Germany), Vol. 85, Issue 2, pp. 119-28, 2007 (PubMed).