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Apolipoprotein A-V (APOA5) (C-Term) antibody

Details for Product No. ABIN375169
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Antigen
Synonyms RAP3, Apoav, 1300007O05Rik, APOAV, apo-AV, apoA-V, APOA5, MGC140487, rap3, apoav, apoa-v
Epitope
C-Term
(12), (10), (3), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(97), (14), (14), (12), (8), (1)
Host
Goat
(59), (40), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(79), (75), (11), (10), (9), (6), (4), (1), (1)
Pubmed 1 reference available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Catalog No. ABIN375169
357.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Peptide with sequence C-HSLHDQGHSHLGDP, from the C Terminus of the protein sequence
Specificity This antibody reacts to APOA5.
Purification Affinity chromatography
Alternative Name Apolipoprotein A V (ApoA V)
Background Apolipoprotein A V is a minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. It may also be associated with chylomicrons. It is an important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). Apolipoprotein A V activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Apolipoprotein A V is upregulated by PPARA agonists, which are used clinically to lower serum TG (such as fibrates). It is induced in early phase of liver regeneration. Defects in Apolipoprotein A V gene are a cause of susceptibility to familial hypertriglyceridemia. It is a coronary heart disease risk factor. On a regular diet the patient demonstrates increased plasma VLDL. Plasma triglycerides are persistently increased, while plasma cholesterol and phospholipids are usually within normal limits.
Alternate names: APOA5, Apo-AV, ApoA-V, Apolipoprotein A-V, RAP3, Regeneration-associated protein 3
Gene ID 116519
NCBI Accession 9606
UniProt Q6Q788
Research Area Metabolism
Application Notes Peptide ELISA: 1/64000. Western Blot: 0.3 - 1 µg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0,5 mg/mL
Buffer Tris buffered saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Apolipoprotein A-V (APOA5) (C-Term) antibody anti-Apolipoprotein A-V (APOA5) (C-Term) antibody
Background publications Corella, Lai, Demissie et al.: "APOA5 gene variation modulates the effects of dietary fat intake on body mass index and obesity risk in the Framingham Heart Study." in: Journal of molecular medicine (Berlin, Germany), Vol. 85, Issue 2, pp. 119-28, 2007 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN375169
357.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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