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Details for Product No. ABIN375169

Apolipoprotein A-V (APOA5) (C-Term) antibody

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Synonyms RAP3, Apoav, 1300007O05Rik, APOAV, apo-AV, apoA-V, APOA5, MGC140487, rap3, apoav, apoa-v
»Alternatives C-Term
»Alternatives Human
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives ELISA, Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN375169
Quantity 0.1 mg
346.50 $   Plus shipping costs $45.00
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Immunogen Peptide with sequence C-HSLHDQGHSHLGDP, from the C Terminus of the protein sequence
Specificity This antibody reacts to APOA5.
Purification Affinity chromatography
Alternative Name Apolipoprotein A V (ApoA V)
Background Apolipoprotein A V is a minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. It may also be associated with chylomicrons. It is an important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). Apolipoprotein A V activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Apolipoprotein A V is upregulated by PPARA agonists, which are used clinically to lower serum TG (such as fibrates). It is induced in early phase of liver regeneration. Defects in Apolipoprotein A V gene are a cause of susceptibility to familial hypertriglyceridemia. It is a coronary heart disease risk factor. On a regular diet the patient demonstrates increased plasma VLDL. Plasma triglycerides are persistently increased, while plasma cholesterol and phospholipids are usually within normal limits.
Alternate names: APOA5, Apo-AV, ApoA-V, Apolipoprotein A-V, RAP3, Regeneration-associated protein 3
Gene ID 116519
NCBI Accession 9606
UniProt Q6Q788
Research Area Metabolism
Application Notes Peptide ELISA: 1/64000. Western Blot: 0.3 - 1 µg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0,5 mg/mL
Buffer Tris buffered saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Corella, Lai, Demissie et al.: "APOA5 gene variation modulates the effects of dietary fat intake on body mass index and obesity risk in the Framingham Heart Study." in: Journal of molecular medicine (Berlin, Germany), Vol. 85, Issue 2, pp. 119-28, 2007 (PubMed).

Alternatives for antigen "Apolipoprotein A-V (APOA5)", type "Antibodies"
Hosts (64), (37), (4)
Reactivities (100), (13), (13), (12), (9)
Applications (82), (74), (10), (7), (7), (5), (2), (1)
Conjugates (5), (5), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (11), (10), (3), (2), (1)