APOA5 antibody

Catalog No. ABIN1724647

Product Details anti-APOA5 Antibody

Target: APOA5 (Apolipoprotein A-V (APOA5))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This APOA5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Purification: purified

Immunogen: Purified recombinant fragment of human Apoa5 expressed in E. coli.

Clone: 2G1H11

Isotype: IgG1

Application Details

Application Notes: ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: 1:200 - 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

References for anti-APOA5 antibody (ABIN1724647)

Prieur, Coste, Rodriguez: "The human apolipoprotein AV gene is regulated by peroxisome proliferator-activated receptor-alpha and contains a novel farnesoid X-activated receptor response element." in: The Journal of biological chemistry, Vol. 278, Issue 28, pp. 25468-80, (2003) (PubMed).

Pennacchio, Olivier, Hubacek, Cohen, Cox, Fruchart, Krauss, Rubin: "An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing." in: Science (New York, N.Y.), Vol. 294, Issue 5540, pp. 169-73, (2001) (PubMed).

Target Details for APOA5

Target: APOA5 (Apolipoprotein A-V (APOA5))

Alternative Name: APOA5 (APOA5 Products)

Synonyms: APOAV antibody, RAP3 antibody, 1300007O05Rik antibody, Apoav antibody, apo-AV antibody, apoA-V antibody, APOA5 antibody, MGC140487 antibody, rap3 antibody, apoav antibody, apoa-v antibody, apolipoprotein A5 antibody, apolipoprotein A-V antibody, apolipoprotein A5 L homeolog antibody, APOA5 antibody, Apoa5 antibody, apoa5.L antibody, apoa5 antibody

Background:

Description: Apolipoprotein A5 (ApoA5) is fast gaining attention as a key regulator of serum triglyceride concentrations. An ApoA5 mouse knock-out model produced an approximately four fold increase in serum triglycerides, whereas a knock-in model with human ApoA5 produced 50-70 % lower concentrations of mouse serum triglycerides. In addition, peroxisome proliferator-activated receptor- agonists, which are used clinically to lower serum triglyceride concentrations, cause increased ApoA5 mRNA expression. Despite these compelling molecular biology data, relatively little is known about ApoA5 protein in human serum. This antibody pair detected recombinant apoa5 protein in sandwich ELISA format and could be potential reagents for the development of clinical diagnostic kits.

Aliases: RAP3, APOAV, APOA-V, MGC126836, MGC126838

Gene ID: 116519

HGNC: 116519

Pathways: Regulation of Lipid Metabolism by PPARalpha, Lipid Metabolism