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VEGFC antibody (Vascular Endothelial Growth Factor C) (C-Term)

Details for Product anti-VEGFC Antibody No. ABIN387759, Supplier: Log in to see
Antigen
  • VEGFC
  • vegf-c
  • xvegf-c
  • Flt4-L
  • VRP
  • AW228853
  • VEGF-C
Alternatives
anti-Human VEGFC antibody for Enzyme Immunoassay
Epitope
C-Term, N-Term
22
17
15
13
13
11
11
8
6
5
4
3
2
2
2
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
164
59
43
4
3
2
2
1
1
1
1
1
Host
Mouse
168
49
8
1
Clonality (Clone)
Monoclonal ()
Conjugate
This VEGFC antibody is un-conjugated
20
19
15
7
7
7
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
167
108
82
22
22
11
7
6
6
5
3
1
Supplier
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Immunogen This monoclonal antibody is generated from mice immunized with three KLH conjugated synthetic peptides selected from the N-terminal, central, and C-terminal regions of human VEGF3.
Clone 30AT1174-77
Isotype IgG1
Specificity This monoclonal antibody is generated from mice immunized with three KLH conjugated synthetic peptides selected from the N-terminal, central, and C-terminal regions of human VEGF3.
Purification This antibody is purified through a protein G column, followed by dialysis against PBS.
Alternative Name VEGF3 (VEGFC Antibody Abstract)
Background The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D.
Synonyms: Vascular Endothelial Growth Factor C, VEGF-C, Vascular endothelial growth factor-related protein, VRP, Flt4 ligand, Flt4-L, VEGF3
Molecular Weight 46883 DA
Gene ID 7424
UniProt P49767
Research Area Cell Signaling, Cell Structure, Cancer, Cell Cycle
Pathways RTK Signaling
Application Notes WB = 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-VEGFC antibody (Vascular Endothelial Growth Factor C) (C-Term) (ABIN387759) Western analysis of extracts from HDMEC cells using VEGF3 antibody.
Background publications Romero, Friel, Velez Edwards et al.: "A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM)." in: American journal of obstetrics and gynecology, Vol. 203, Issue 4, pp. 361.e1-361.e30, 2010 (PubMed).

Deguchi, Ichikawa, Soga et al.: "Clinical significance of vascular endothelial growth factors C and D and chemokine receptor CCR7 in gastric cancer." in: Anticancer research, Vol. 30, Issue 6, pp. 2361-6, 2010 (PubMed).

Johnatty, Beesley, Chen et al.: "Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"." in: PLoS genetics, Vol. 6, Issue 7, pp. e1001016, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Romero, Velez Edwards, Kusanovic et al.: "Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes." in: American journal of obstetrics and gynecology, Vol. 202, Issue 5, pp. 431.e1-34, 2010 (PubMed).