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SMT3 Suppressor of Mif Two 3 Homolog 3 (S. Cerevisiae) (SUMO3) antibody

Details for Product No. ABIN387787
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Antigen
Synonyms
smt3a, smt3h1, fa94a11, im:7141764, sumo2, sumo3, sumo3l, wu:fa94a11, wu:fb55d09, zgc:65847, zgc:85643, fc66f10, fl11h12, wu:fc66f10, wu:fl11h12, zgc:86902, SUMO3, HSMT3, SMT3B, SMT3H2, Smt3A, SMT3A,  ... show more
smt3a, smt3h1, fa94a11, im:7141764, sumo2, sumo3, sumo3l, wu:fa94a11, wu:fb55d09, zgc:65847, zgc:85643, fc66f10, fl11h12, wu:fc66f10, wu:fl11h12, zgc:86902, SUMO3, HSMT3, SMT3B, SMT3H2, Smt3A, SMT3A, SMT3H1, SUMO-3, Smt3B, ATSUMO3, MCO15.12, MCO15_12, SMALL UBIQUITIN-LIKE MODIFIER 3, SUM3, SUMO 3, small ubiquitin-like modifier 3, 2810014B19Rik, AA409334, AW121497, AW536077, D10Ertd345e, Smt3h1 show less
Reactivity
Human
(65), (26), (22), (12), (12), (12), (12)
Host
Mouse
(50), (16), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(56), (39), (20), (10), (8), (2), (2), (1)
Pubmed 5 references available
Quantity 400 µL
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Catalog No. ABIN387787
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Immunogen Purified recombinant GST-SUMO3 fusion protein was used as immunogen.
Clone 76AT630-91-31
Isotype IgG1
Specificity Purified recombinant GST-SUMO3 fusion protein was used as immunogen.
Purification This antibody is purified through a protein G column, followed by dialysis against PBS.
Alternative Name SUMO3
Background SUMO proteins, such as SUMO3, and ubiquitin (see MIM 191339) posttranslationally modify numerous cellular proteins and affect their metabolism and function. However, unlike ubiquitination, which targets proteins for degradation, sumoylation participates in a number of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability (Su and Li, 2002 [PubMed 12383504]).
Synonyms: Small ubiquitin-related modifier 3, SUMO-3, Ubiquitin-like protein SMT3A, SMT3 homolog 1, SUMO-2, SMT3A, SMT3H1
Molecular Weight 11637 DA
Gene ID 6612
UniProt P55854
Research Area Apoptosis/Necrosis, Cell Signaling, Protein Modifications, Transcription Factors, Signaling, Cell Structure
Application Notes WB = 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 0.35 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-SMT3 Suppressor of Mif Two 3 Homolog 3 (S. Cerevisiae) (SUMO3) antibody The anti-SUMO3 monoclonal antibody (ABIN387787) is used in Western blot to detect GST-SUMO3 fusion protein (left) and SUMO3 in Jurkat cell lysate (right).
Background publications Brunet Simioni, De Thonel, Hammann et al.: "Heat shock protein 27 is involved in SUMO-2/3 modification of heat shock factor 1 and thereby modulates the transcription factor activity." in: Oncogene, Vol. 28, Issue 37, pp. 3332-44, 2009 (PubMed).

Hofmann, Arduini, Nicol et al.: "SUMOylation of nuclear actin." in: The Journal of cell biology, Vol. 186, Issue 2, pp. 193-200, 2009 (PubMed).

Uwada, Tanaka, Yamaguchi et al.: "The p150 subunit of CAF-1 causes association of SUMO2/3 with the DNA replication foci." in: Biochemical and biophysical research communications, Vol. 391, Issue 1, pp. 407-13, 2010 (PubMed).

Couch, Wang, Bamlet et al.: "Association of mitotic regulation pathway polymorphisms with pancreatic cancer risk and outcome." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 1, pp. 251-7, 2010 (PubMed).

Han, Huang, Sun et al.: "SENP3-mediated de-conjugation of SUMO2/3 from promyelocytic leukemia is correlated with accelerated cell proliferation under mild oxidative stress." in: The Journal of biological chemistry, Vol. 285, Issue 17, pp. 12906-15, 2010 (PubMed).

Validation Images
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