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Details for Product No. ABIN387798

SRY (Sex Determining Region Y)-Box 2 (SOX2) antibody

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Antigen
Synonyms ANOP3, MCOPS3, RGD1565646, Qsox, rSOx, Qscn6, Sox-2, cb236, wu:fb83g04, wu:fc14d07, zgc:65860, zgc:77389, SRY-box2, Xsox-2, anop3, mcops3, sox-2
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunofluorescence (IF), Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
Pubmed 5 references available
Catalog no. ABIN387798
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen SOX2 recombinant protein is used to produce this monoclonal antibody.
Clone 57CT23-3-4
Isotype IgG1
Specificity SOX2 recombinant protein is used to produce this monoclonal antibody.
Purification This antibody is purified through a protein G column, followed by dialysis against PBS.
Alternative Name SOX2
Background This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).
Synonyms: Transcription factor SOX-2
Molecular Weight 34310 Da predicted from amino acid sequence. Theoretical pI=9.74 Da
Gene ID 6657
UniProt P48431
Research Area Stem Cells, Transcription Factors, Signaling
Application Notes Recommend dilutions: IF : 1:100,WB : 1:200-2000,IHC : 1:50-100,FC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.36 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Reis, Tyler, Schneider et al.: "Examination of SOX2 in variable ocular conditions identifies a recurrent deletion in microphthalmia and lack of mutations in other phenotypes." in: Molecular vision, Vol. 16, pp. 768-73, 2010 (PubMed).

Gonzalez-Rodriguez, Pelcastre, Tovilla-Canales et al.: "Mutational screening of CHX10, GDF6, OTX2, RAX and SOX2 genes in 50 unrelated microphthalmia-anophthalmia-coloboma (MAC) spectrum cases." in: The British journal of ophthalmology, Vol. 94, Issue 8, pp. 1100-4, 2010 (PubMed).

Ge, Zhou, Chen et al.: "Sox2 is translationally activated by eukaryotic initiation factor 4E in human glioma-initiating cells." in: Biochemical and biophysical research communications, Vol. 397, Issue 4, pp. 711-7, 2010 (PubMed).

Sholl, Barletta, Yeap et al.: "Sox2 protein expression is an independent poor prognostic indicator in stage I lung adenocarcinoma." in: The American journal of surgical pathology, Vol. 34, Issue 8, pp. 1193-8, 2010 (PubMed).

Zhang, Efendic, Brismar et al.: "Effects of MCF2L2, ADIPOQ and SOX2 genetic polymorphisms on the development of nephropathy in type 1 Diabetes Mellitus." in: BMC medical genetics, Vol. 11, pp. 116, 2010 (PubMed).

Alternatives for antigen "SRY (Sex Determining Region Y)-Box 2 (SOX2)", type "Antibodies"
Hosts (127), (29), (4)
Reactivities (147), (62), (41), (22), (21), (20), (17), (12), (6), (5), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1)
Applications (118), (46), (37), (26), (22), (18), (12), (10), (10), (5), (4), (1)
Conjugates (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (26), (7), (6), (4), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1)
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