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Details for Product No. ABIN388101

BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (AA 130-165), (BH3 Domain) antibody

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Synonyms BAM, BIM, BOD, Bim, Bod, 1500006F24Rik, BimL, bim
»Alternatives AA 130-165, BH3 Domain
»Alternatives Human
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 5 references available
Catalog no. ABIN388101
Quantity 400 µL
291.50 $   Plus shipping costs $45.00
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Immunogen This Bim BH3 Domain antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 130-165 AA from human Bim BH3 Domain.
Clone RB00963
Isotype Ig
Specificity This Bim BH3 Domain antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide encoding the BH3 domain of human Bim.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name Bim
Background Bim belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Bim contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection.
Synonyms: Bcl-2-like protein 11, Bcl2 interacting mediator of cell death
Molecular Weight 22171 DA
Gene ID 10018
UniProt O43521
Research Area Apoptosis/Necrosis, Cancer, Cell Cycle, Transcription Factors, Signaling, Neurology, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Chen, Wang, Zhou et al.: "HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim." in: The EMBO journal, Vol. 21, Issue 24, pp. 6801-10, 2002 (PubMed).

Reginato, Mills, Paulus et al.: "Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis." in: Nature cell biology, Vol. 5, Issue 8, pp. 733-40, 2003 (PubMed).

Sunters, Fernández de Mattos, Stahl et al.: "FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines." in: The Journal of biological chemistry, Vol. 278, Issue 50, pp. 49795-805, 2003 (PubMed).

Luciano, Jacquel, Colosetti et al.: "Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function." in: Oncogene, Vol. 22, Issue 43, pp. 6785-93, 2003 (PubMed).

Chen, Zhou: "Caspase cleavage of BimEL triggers a positive feedback amplification of apoptotic signaling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 5, pp. 1235-40, 2004 (PubMed).

Alternatives for antigen "BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11)", type "Antibodies"
Hosts (151), (15), (12), (7), (3)
Reactivities (168), (129), (107), (37), (36), (24), (2), (1), (1)
Applications (124), (56), (47), (40), (37), (32), (20), (19), (16), (5), (5), (3), (3), (3)
Conjugates (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Epitopes (21), (15), (12), (12), (9), (8), (4), (4), (4), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)