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BIM antibody (BCL2-Like 11 (Apoptosis Facilitator)) (AA 130-165)

Details for Product anti-BCL2L11 Antibody No. ABIN388101, Supplier: Login to see New
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Synonyms bim, BAM, BIM, BOD, 1500006F24Rik, Bim, Bod, BimL, BIMEL
AA 130-165, BH3 Domain
(78), (22), (16), (14), (13), (13), (13), (13), (10), (8), (7), (7), (7), (5), (4), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
(287), (145), (109), (4), (2), (2), (2), (2), (2)
(257), (20), (16), (16), (7)
Clonality (Clone)
Polyclonal ()
This BIM antibody is un-conjugated
(17), (15), (9), (8), (8), (8), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(232), (135), (102), (53), (42), (36), (35), (26), (16), (8), (3), (3), (2), (2), (2)
Pubmed 6 references available
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Quantity 400 μL
Shipping to United States ( )
Availability Will be delivered in 2 to 4 Business Days
Immunogen This Bim BH3 Domain antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 130-165 AA from human Bim BH3 Domain.
Clone RB00963
Isotype Ig
Specificity This Bim BH3 Domain antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide encoding the BH3 domain of human Bim.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name Bim (BCL2L11 Antibody Abstract)
Background Bim belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Bim contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection.
Synonyms: Bcl-2-like protein 11, Bcl2 interacting mediator of cell death
Molecular Weight 22171 DA
Gene ID 10018
UniProt O43521
Research Area Apoptosis/Necrosis, Cancer, Cell Cycle, Transcription Factors, Signaling, Neurology, Cell Structure
Pathways PI3K-Akt Signaling, Neurotrophin Signaling Pathway
Application Notes WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-BIM antibody (BCL2-Like 11 (Apoptosis Facilitator)) (AA 130-165) (ABIN388101) The anti-Bim BH3 domain Pab (ABIN388101) is used in Western blot to detect Bim BH3 in...
Immunohistochemistry (IHC) image for anti-BIM antibody (BCL2-Like 11 (Apoptosis Facilitator)) (AA 130-165) (ABIN388101) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Product cited in: Del Gaizo Moore, Schlis, Sallan et al.: "BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia." in: Blood, Vol. 111, Issue 4, pp. 2300-9, 2008 (PubMed).

Background publications Chen, Zhou: "Caspase cleavage of BimEL triggers a positive feedback amplification of apoptotic signaling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 5, pp. 1235-40, 2004 (PubMed).

Luciano, Jacquel, Colosetti et al.: "Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function." in: Oncogene, Vol. 22, Issue 43, pp. 6785-93, 2003 (PubMed).

Sunters, Fernández de Mattos, Stahl et al.: "FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines." in: The Journal of biological chemistry, Vol. 278, Issue 50, pp. 49795-805, 2003 (PubMed).

Reginato, Mills, Paulus et al.: "Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis." in: Nature cell biology, Vol. 5, Issue 8, pp. 733-40, 2003 (PubMed).

Chen, Wang, Zhou et al.: "HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim." in: The EMBO journal, Vol. 21, Issue 24, pp. 6801-10, 2002 (PubMed).

Catalog No. ABIN388101
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