Ubiquitin-Conjugating Enzyme E2L 6 (UBE2L6) (AA 123-153), (C-Term) antibody

Details for Product No. ABIN388854
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Synonyms UBE2L6, RIG-B, UBCH8, 2810489I21Rik, Ubce8, Ubcm8, UbcM8
AA 123-153, C-Term
(16), (14), (13), (13), (7), (6), (2), (2), (1)
(78), (13), (13), (1), (1), (1)
(52), (26)
Clonality (Clone)
Polyclonal ()
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(62), (35), (23), (10), (10), (7), (4), (3), (3), (1)
Pubmed 3 references available
Quantity 400 μL
Shipping to United States ( )
Availability Will be delivered in 2 to 4 Business Days
Immunogen This UBE2L6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 123-153 AA from the C-terminal region of human UBE2L6.
Clone RB4157
Isotype Ig
Specificity This UBE2L6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 124~153 amino acids from the C-terminal region of human UBE2L6.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name UBE2L6 (UBE2L6 Antibody Abstract)
Background The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). UBE2L6 is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to function in the E6/E6-ap-induced ubiquitination of p53.
Synonyms: Ubiquitin/ISG15-conjugating enzyme E2 L6, Ubiquitin-protein ligase L6, Ubiquitin carrier protein L6, UbcH8, Retinoic acid-induced gene B protein, RIG-B
Molecular Weight 17637 DA
Gene ID 9246
UniProt O14933
Research Area Ubiquitin-related antibodies, Cell Signaling, Protein Modifications, Cell Structure
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Ubiquitin-Conjugating Enzyme E2L 6 (UBE2L6) (AA 123-153), (C-Term) antibody (ABIN388854) The UBE2L6 Antibody (C-term) (ABIN388854) is used in Western blot to detect UBE2L6 in...
Immunohistochemistry (IHC) image for anti-Ubiquitin-Conjugating Enzyme E2L 6 (UBE2L6) (AA 123-153), (C-Term) antibody (ABIN388854) Formalin-fixed and paraffin-embedded breast carcinoma tissue reacted with UBE2L6 Anti...
Product cited in: Pietschmann, Buchwald, Müller et al.: "Differential regulation of PML-RARα stability by the ubiquitin ligases SIAH1/SIAH2 and TRIAD1." in: The international journal of biochemistry & cell biology, Vol. 44, Issue 1, pp. 132-8, 2011 (PubMed).

Krämer, Müller, Buchwald et al.: "Mechanism for ubiquitylation of the leukemia fusion proteins AML1-ETO and PML-RARalpha." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 22, Issue 5, pp. 1369-79, 2008 (PubMed).

Background publications Kumar, Kao, Howley: "Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativity." in: The Journal of biological chemistry, Vol. 272, Issue 21, pp. 13548-54, 1997 (PubMed).

Catalog No. ABIN388854
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