UBE2L6 antibody (N-Term)

Catalog No. ABIN1882146

Product Details anti-UBE2L6 Antibody

Target: UBE2L6 (Ubiquitin-Conjugating Enzyme E2L 6 (UBE2L6))

Binding Specificity: AA 1-30, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBE2L6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This UBE2L6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human UBE2L6.

Clone: RB4156

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-UBE2L6 antibody (ABIN1882146)

Takenokuchi, Miyamoto, Saigo, Taniguchi: "Bortezomib Causes ER Stress-related Death of Acute Promyelocytic Leukemia Cells Through Excessive Accumulation of PML-RARA." in: Anticancer research, Vol. 35, Issue 6, pp. 3307-16, (2015) (PubMed).

Hsiang, Zhao, Krug: "Interferon-induced ISG15 conjugation inhibits influenza A virus gene expression and replication in human cells." in: Journal of virology, Vol. 83, Issue 12, pp. 5971-7, (2009) (PubMed).

Makki, Heinzel, Englert: "TSA downregulates Wilms tumor gene 1 (Wt1) expression at multiple levels." in: Nucleic acids research, Vol. 36, Issue 12, pp. 4067-78, (2008) (PubMed).

Kumar, Kao, Howley: "Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativity." in: The Journal of biological chemistry, Vol. 272, Issue 21, pp. 13548-54, (1997) (PubMed).

Target Details for UBE2L6

Target: UBE2L6 (Ubiquitin-Conjugating Enzyme E2L 6 (UBE2L6))

Alternative Name: UBE2L6 (UBE2L6 Products)

Synonyms: UBE2L6 antibody, RIG-B antibody, UBCH8 antibody, 2810489I21Rik antibody, Ubce8 antibody, Ubcm8 antibody, UbcM8 antibody, ubiquitin conjugating enzyme E2 L6 antibody, ubiquitin-conjugating enzyme E2L 6 antibody, UBE2L6 antibody, Ube2l6 antibody

Background: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). UBE2L6 is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to function in the E6/E6-ap-induced ubiquitination of p53.

Molecular Weight: 17769

NCBI Accession: NP_004214, NP_937826

UniProt: O14933