Poly(A) Binding Protein, Cytoplasmic 1 (PABPC1) (AA 250-279), (Center) antibody

Details for Product No. ABIN389462
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Antigen
Synonyms
fi20g03, pab-2, wu:fi20g03, zgc:55855, pab1, pabp, pabp1, pabpc2, PABPC1, pabpc1, wu:fb16a02, wu:fi19b08, wu:fj12d09, wu:fj61f06, zgc:109879, PAB1, PABP, PABP1, PABPC2, PABPL1, Pabp1, PabpI, Pabpl1, e ... show more
fi20g03, pab-2, wu:fi20g03, zgc:55855, pab1, pabp, pabp1, pabpc2, PABPC1, pabpc1, wu:fb16a02, wu:fi19b08, wu:fj12d09, wu:fj61f06, zgc:109879, PAB1, PABP, PABP1, PABPC2, PABPL1, Pabp1, PabpI, Pabpl1, ePAB, Pabp show less
Epitope
AA 250-279, Center
(12), (12), (3), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(41), (25), (22), (17), (13), (12), (12), (5), (4), (1)
Host
Rabbit
(34), (9)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(34), (18), (15), (13), (10), (9), (7), (6), (2), (2), (1), (1)
Pubmed 1 reference available
Quantity 400 μL
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Catalog No. ABIN389462
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Immunogen This PABPC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-279 AA from the Central region of human PABPC1.
Clone RB20873
Isotype Ig
Specificity This PABPC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 257~287 amino acids from the Center region of human PABPC1.
Predicted Reactivity Cow (Bovine),Rat (Rattus),Xenopus laevis
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name PABPC1
Background PABPC1 binds the poly(A) tail of mRNA. It may be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. PABPC1 can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. It may be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.
Synonyms: Polyadenylate-binding protein 1, Poly(A)-binding protein 1, PABP 1, PABPC2, PABP1, PAB1, PABPC1
Molecular Weight 70671 DA
Gene ID 26986
UniProt P11940
Research Area Stem Cells
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Poly(A) Binding Protein, Cytoplasmic 1 (PABPC1) (AA 250-279), (Center) antibody Western blot analysis of PABPC1 Antibody (Center) (ABIN389462) in NIH-3T3 cell line lysates (35 µg/lane). PABPC1 (arrow) was detected using the purified polyclonal antibody.
anti-Poly(A) Binding Protein, Cytoplasmic 1 (PABPC1) (AA 250-279), (Center) antibody (2) Formalin-fixed and paraffin-embedded human lung carcinoma reacted with PABPC1 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Background publications Le Clerc, Limou, Coulonges et al.: "Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03)." in: The Journal of infectious diseases, Vol. 200, Issue 8, pp. 1194-201, 2009 (PubMed).

Validation Images
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