PABP antibody (meArg455, meArg460)

Catalog No. ABIN704831

Product Details anti-PABP Antibody

Target: PABP (PABPC1) (Poly(A) Binding Protein, Cytoplasmic 1 (PABPC1))

Binding Specificity: meArg455, meArg460

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PABP antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Cow,Pig,Horse,Chicken,Rabbit,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic metylpeptide derived from human PABP around metylation site of Arg455/Arg460

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for PABP

Target: PABP (PABPC1) (Poly(A) Binding Protein, Cytoplasmic 1 (PABPC1))

Alternative Name: Pabp (PABPC1 Products)

Synonyms: PAB1 antibody, PABP antibody, PABP1 antibody, PABPC2 antibody, PABPL1 antibody, Pabp1 antibody, PabpI antibody, Pabpl1 antibody, ePAB antibody, Pabp antibody, pab1 antibody, pabp antibody, pabp1 antibody, pabpc1 antibody, pabpc2 antibody, PABPC1 antibody, wu:fb16a02 antibody, wu:fi19b08 antibody, wu:fj12d09 antibody, wu:fj61f06 antibody, zgc:109879 antibody, zgc:77608 antibody, poly(A) binding protein cytoplasmic 1 antibody, poly(A) binding protein, cytoplasmic 1 antibody, poly(A) binding protein, cytoplasmic 1 S homeolog antibody, poly(A) binding protein cytoplasmic 1 like antibody, poly(A) binding protein, cytoplasmic 1 L homeolog antibody, poly(A) binding protein, cytoplasmic 1a antibody, poly A binding protein, cytoplasmic 1 b antibody, PABPC1 antibody, Pabpc1 antibody, pabpc1.S antibody, pabpc1 antibody, PABPC1L antibody, pabpc1.L antibody, pabpc1a antibody, pabpc1b antibody

Background:

Synonyms: PAB1, PABP, PABP1, PABPC2, PABPL1, Polyadenylate-binding protein 1, PABP-1, Poly(A)-binding protein 1, PABPC1

Background: Binds the poly(A) tail of mRNA, including that of its own transcript. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons, for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed.

Gene ID: 26986

UniProt: P11940

Pathways: SARS-CoV-2 Protein Interactome