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PRKDC antibody (pThr2609)

PRKDC Reactivity: Human DB Host: Rabbit Polyclonal RB8113 unconjugated
Catalog No. ABIN389868
  • Target See all PRKDC Antibodies
    PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC))
    Binding Specificity
    • 25
    • 13
    • 12
    • 7
    • 7
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pThr2609
    Reactivity
    • 161
    • 86
    • 47
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    Human
    Host
    • 150
    • 22
    • 3
    • 2
    Rabbit
    Clonality
    • 147
    • 30
    Polyclonal
    Conjugate
    • 89
    • 11
    • 10
    • 7
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    This PRKDC antibody is un-conjugated
    Application
    • 79
    • 67
    • 56
    • 30
    • 30
    • 28
    • 27
    • 24
    • 14
    • 13
    • 6
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    Dot Blot (DB)
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This DNA-PK Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T2609 of human DNA-PK.
    Clone
    RB8113
    Isotype
    Ig Fraction
    Top Product
    Discover our top product PRKDC Primary Antibody
  • Application Notes
    DB: 1:500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Target
    PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC))
    Alternative Name
    DNA-PK (PRKDC Products)
    Background
    Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Stem cell surface receptors and activate yeast MAPK pathway.
    Molecular Weight
    469089
    Gene ID
    5591
    NCBI Accession
    NP_001075109, NP_008835
    UniProt
    P78527
    Pathways
    DNA Damage Repair, Production of Molecular Mediator of Immune Response
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