anti-MAPK10 antibody (Mitogen-Activated Protein Kinase 10) (AA 7-34)

Details for Product anti-MAPK10 Antibody No. ABIN391327
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Synonyms MAPK10, zgc:123234, DKFZp459H0638, Jnk3, SAPKC, SAPb, Serk2, JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK, C230008H04Rik, JNK3B1, JNK3B2, SAPK(beta), ATMPK10, MAP kinase 10
AA 7-34, N-Term
(45), (16), (8), (8), (6), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1)
(112), (49), (35)
(100), (21)
Clonality (Clone)
Polyclonal ()
This MAPK10 antibody is un-conjugated
(8), (7), (6), (5), (5), (5), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(106), (72), (52), (16), (12), (11), (10), (9), (3), (3), (2), (1), (1)
Pubmed 4 references available
Quantity 400 μL
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Availability Will be delivered in 2 to 4 Business Days
Immunogen This MAPK10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7-34 AA from the N-terminal region of human MAPK10.
Clone RB03190
Isotype Ig
Specificity This MAPK10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13~42 amino acids from the N-terminal region of human MAPK10.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name MAPK10 (MAPK10 Antibody Abstract)
Background MAPK10 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kinase 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis.
Synonyms: Mitogen-activated protein kinase 10, Stress-activated protein kinase JNK3, MAP kinase p49 3F12
Molecular Weight 52585 DA
Gene ID 5602
UniProt P53779
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Cycle, Transcription Factors, Signaling, Neurology, Cell Structure
Pathways MAPK Signaling, WNT Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-MAPK10 antibody (Mitogen-Activated Protein Kinase 10) (AA 7-34) (ABIN391327) MAPK10 Antibody (C21) (ABIN391327) western blot analysis in 293 cell line lysates (35...
Background publications Yoshida, Harada, Nagai et al.: "Head-to-head juxtaposition of Fas-associated phosphatase-1 (FAP-1) and c-Jun NH2-terminal kinase 3 (JNK3) genes: genomic structure and seven polymorphisms of the FAP-1 gene." in: Journal of human genetics, Vol. 47, Issue 11, pp. 614-9, 2002 (PubMed).

McDonald, Chow, Miller et al.: "Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3." in: Science (New York, N.Y.), Vol. 290, Issue 5496, pp. 1574-7, 2000 (PubMed).

Yang, Kuan, Whitmarsh et al.: "Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene." in: Nature, Vol. 389, Issue 6653, pp. 865-70, 1997 (PubMed).

Gupta, Barrett, Whitmarsh et al.: "Selective interaction of JNK protein kinase isoforms with transcription factors." in: The EMBO journal, Vol. 15, Issue 11, pp. 2760-70, 1996 (PubMed).

Catalog No. ABIN391327
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