Mitogen-Activated Protein Kinase 10 (MAPK10) (N-Term), (AA 1-30) antibody

Details for Product No. ABIN391727
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Antigen
Synonyms MAPK10, zgc:123234, DKFZp459H0638, Jnk3, SAPKC, SAPb, Serk2, JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK, C230008H04Rik, JNK3B1, JNK3B2, SAPK(beta), ATMPK10, MAP kinase 10
Epitope
N-Term, AA 1-30
(22), (8), (7), (6), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(91), (39), (33), (12), (12), (12), (12)
Host
Rabbit
(68), (23)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(4), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(83), (58), (24), (16), (13), (11), (10), (4), (2), (2), (1)
Pubmed 4 references available
Quantity 400 μL
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Catalog No. ABIN391727
291.50 $
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Immunogen This MAPK10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 AA from the N-terminal region of human MAPK10.
Clone RB01017
Isotype Ig
Specificity This JNK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1~30 amino acids from the N-terminal region of human JNK3.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name JNK3
Background JNK3 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kinase 5 can phosphorylate and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis.
Synonyms: c-Jun N-terminal kinase 3, Mitogen-activated protein kinase 10, Stress-activated protein kinase JNK3, MAP kinase p49 3F12
Molecular Weight 52585 DA
Gene ID 5602
UniProt P53779
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Cycle, Transcription Factors, Signaling, Neurology, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Mitogen-Activated Protein Kinase 10 (MAPK10) (N-Term), (AA 1-30) antibody Western blot analysis of anti-JNK3 Antibody (N-term) (ABIN391727) in mouse brain tissue lysates (35 µg/lane). JNK3 (arrow) was detected using the purified polyclonal antibody.
anti-Mitogen-Activated Protein Kinase 10 (MAPK10) (N-Term), (AA 1-30) antibody (2) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
Background publications Gupta, Barrett, Whitmarsh et al.: "Selective interaction of JNK protein kinase isoforms with transcription factors." in: The EMBO journal, Vol. 15, Issue 11, pp. 2760-70, 1996 (PubMed).

Yang, Kuan, Whitmarsh et al.: "Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene." in: Nature, Vol. 389, Issue 6653, pp. 865-70, 1997 (PubMed).

McDonald, Chow, Miller et al.: "Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3." in: Science (New York, N.Y.), Vol. 290, Issue 5496, pp. 1574-7, 2000 (PubMed).

Yoshida, Harada, Nagai et al.: "Head-to-head juxtaposition of Fas-associated phosphatase-1 (FAP-1) and c-Jun NH2-terminal kinase 3 (JNK3) genes: genomic structure and seven polymorphisms of the FAP-1 gene." in: Journal of human genetics, Vol. 47, Issue 11, pp. 614-9, 2002 (PubMed).

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