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Mitogen-Activated Protein Kinase 11 (MAPK11) (C-Term), (AA 334-359) antibody

Details for Product No. ABIN391730
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Antigen
Synonyms zgc:86905, ATMPK11, F22L4.10, F22L4_10, MAP kinase 11, p38b, p38-2, sapk2, prkm11, sapk2b, p38beta, p38beta2, P38B, P38BETA2, PRKM11, SAPK2, SAPK2B, p38Beta, P38b, Prkm11, Sapk2, Sapk2b
Epitope
C-Term, AA 334-359
(13), (13), (10), (9), (8), (6), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(77), (43), (29), (24), (12)
Host
Rabbit
(68), (16)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(61), (30), (21), (20), (12), (4), (4), (2), (2), (1), (1), (1)
Pubmed 5 references available
Quantity 400 µL
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Catalog No. ABIN391730
291.50 $
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Immunogen This MAPK11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 334-359 AA from the C-terminal region of human MAPK11.
Clone RB6825
Isotype Ig
Specificity This P38beta antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human P38beta C-term Antibody.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name P38beta
Background P38 beta is a member of the MAP kinase subfamily of Ser/Thr protein kinases. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is closely related to p38 MAP kinase, both of which can be activated by changes in osmolarity of the extracellular environment, proinflammatory cytokines and cellular stress. This protein preferentially phosphorylates transcription factor ATF2. It is activated by phosphorylation on threonine and tyrosine by MKK6, and inhibited by pyridinyl-imidazole related compounds. Highest levels of expression are found in the brain and heart, with additional expression in the placenta, lung, liver, skeletal muscle, kidney and pancreas.
Synonyms: Mitogen-activated protein kinase 11, Mitogen-activated protein kinase p38 beta, MAP kinase p38 beta, p38b, p38-2, Stress-activated protein kinase-2
UniProt Q2XNF2
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Transcription Factors, Signaling, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Mitogen-Activated Protein Kinase 11 (MAPK11) (C-Term), (AA 334-359) antibody Western blot analysis of anti-P38beta Antibody (C-term) (ABIN391730) in mouse heart tissue lysates (35 µg/lane). P38beta (arrow) was detected using the purified polyclonal antibody.
anti-Mitogen-Activated Protein Kinase 11 (MAPK11) (C-Term), (AA 334-359) antibody (2) P38beta Antibody (C-term) (ABIN391730) western blot analysis in K562 cell line lysates (35 µg/lane).This demonstrates the P38beta antibody detected the P38beta protein (arrow).
Background publications Kumar, McDonnell, Gum et al.: "Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles." in: Biochemical and biophysical research communications, Vol. 235, Issue 3, pp. 533-8, 1997 (PubMed).

Goedert, Cuenda, Craxton et al.: "Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases." in: The EMBO journal, Vol. 16, Issue 12, pp. 3563-71, 1997 (PubMed).

Enslen, Raingeaud, Davis: "Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6." in: The Journal of biological chemistry, Vol. 273, Issue 3, pp. 1741-8, 1998 (PubMed).

Dunham, Shimizu, Roe et al.: "The DNA sequence of human chromosome 22. ..." in: Nature, Vol. 402, Issue 6761, pp. 489-95, 1999 (PubMed).

Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Validation Images
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