MAPK11 antibody (AA 251-363)

Catalog No. ABIN969276

Cited in 2+ publications. The Mouse Monoclonal anti-MAPK11 antibody (Clone 4H6H6) (ABIN969276) specifically detects MAPK11 in ELISA. The antibody is reactive with Human samples.

Quick Overview for MAPK11 antibody (AA 251-363) (ABIN969276)

Target: MAPK11 (Mitogen-Activated Protein Kinase 11 (MAPK11))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MAPK11 antibody is un-conjugated

Application: ELISA

Clone: 4H6H6

Product Details anti-MAPK11 Antibody

Binding Specificity: AA 251-363

Purpose: MAPK11 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of MAPK11 (aa251-363) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-MAPK11 antibody (ABIN969276)

Beardmore, Hinton, Eftychi, Apostolaki, Armaka, Darragh, McIlrath, Carr, Armit, Clacher, Malone, Kollias, Arthur: "Generation and characterization of p38beta (MAPK11) gene-targeted mice." in: Molecular and cellular biology, Vol. 25, Issue 23, pp. 10454-64, (2005) (PubMed).

Johnstone, Sibley, Lowen, Guilbert: "Epidermal growth factor stimulation of trophoblast differentiation requires MAPK11/14 (p38 MAP kinase) activation." in: Biology of reproduction, Vol. 73, Issue 6, pp. 1282-8, (2005) (PubMed).

Target Details for MAPK11

Target: MAPK11 (Mitogen-Activated Protein Kinase 11 (MAPK11))

Alternative Name: MAPK11

Background: Mitogen-activated protein kinase 11.The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase.

UniProt: Q15759

Pathways: MAPK Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Response to Water Deprivation, Regulation of Muscle Cell Differentiation, ER-Nucleus Signaling, Hepatitis C, Toll-Like Receptors Cascades, Signaling Events mediated by VEGFR1 and VEGFR2, Thromboxane A2 Receptor Signaling, BCR Signaling, S100 Proteins