Fibroblast Growth Factor Receptor 3 (FGFR3) (C-Term), (AA 776-806) antibody

Details for Product No. ABIN391969
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Antigen
Synonyms FGFR3, LOC100034114, ACH, CD333, CEK2, HSFGFR3EX, JTK4, FR3, Fgfr-3, Flg-2, HBGFR, Mfr3, sam3, fc27h01, wu:fc27h01
Epitope
C-Term, AA 776-806
(15), (12), (9), (7), (7), (6), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(83), (52), (40), (24), (24), (12), (3), (1), (1), (1)
Host
Rabbit
(94), (3), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(5), (5), (5), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(56), (32), (32), (30), (20), (4), (3), (3), (1), (1), (1), (1)
Pubmed 2 references available
Quantity 400 μL
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Catalog No. ABIN391969
291.50 $
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Immunogen This FGFR3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 776-806 AA from the C-terminal region of human FGFR3.
Clone RB01572
Isotype Ig
Specificity This FGFR3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 777~806 amino acids from the C-terminal region of human FGFR3.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name FGFR3
Background FGFR3 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia.
Synonyms: fibroblast growth factor receptor 3
Molecular Weight 87709 DA
Gene ID 2261
UniProt P22607
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Cell Cycle
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 1.36 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Fibroblast Growth Factor Receptor 3 (FGFR3) (C-Term), (AA 776-806) antibody Western blot analysis of anti-FGFR3 Pab (ABIN391969) in Jurkat cell lysate. FGFR3 (Arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
anti-Fibroblast Growth Factor Receptor 3 (FGFR3) (C-Term), (AA 776-806) antibody (2) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
Background publications Lievens, Liboi: "The thanatophoric dysplasia type II mutation hampers complete maturation of fibroblast growth factor receptor 3 (FGFR3), which activates signal transducer and activator of transcription 1 (STAT1) from the endoplasmic reticulum." in: The Journal of biological chemistry, Vol. 278, Issue 19, pp. 17344-9, 2003 (PubMed).

Sturla, Merrick, Burchill: "FGFR3IIIS: a novel soluble FGFR3 spliced variant that modulates growth is frequently expressed in tumour cells." in: British journal of cancer, Vol. 89, Issue 7, pp. 1276-84, 2003 (PubMed).

Validation Images
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