FGFR3 antibody (AA 776-806)

Catalog No. ABIN3030957

The Rabbit Polyclonal anti-FGFR3 antibody (ABIN3030957) specifically detects FGFR3 in WB, IHC and ELISA. The antibody is reactive with Human samples.

Quick Overview for FGFR3 antibody (AA 776-806) (ABIN3030957)

Target: FGFR3 (Fibroblast Growth Factor Receptor 3 (FGFR3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FGFR3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-FGFR3 Antibody

Binding Specificity: AA 776-806

Purpose: FGFR3 Antibody

Purification: Purified

Immunogen: A portion of amino acids 776-806 from the human protein was used as the immunogen for this FGFR3 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the FGFR3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the FGFR3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for FGFR3

Target: FGFR3 (Fibroblast Growth Factor Receptor 3 (FGFR3))

Alternative Name: FGFR3

Background: FGFR3 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia.

UniProt: P22607

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Growth Factor Binding