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Pancreatic and Duodenal Homeobox 1 (PDX1) (AA 186-215), (C-Term) antibody

Details for Product No. ABIN392141, Supplier: Login to see
Antigen
  • ipf1
  • PDX1
  • Ad4BP
  • ELP
  • ELP-3
  • Ftz-F1
  • Ftzf1
  • SF-1
  • SF1
  • Ad4BP/SF-1
  • Ad4bp
  • Sf-1
  • GSF
  • IDX-1
  • IPF1
  • IUF1
  • MODY4
  • PDX-1
  • STF-1
  • IPF-1
  • Ipf1
  • Mody4
  • pdx-1
  • Idx1
  • Stf1
  • zgc:100874
  • XlHbox-8
  • xlhbox8
Alternatives
anti-Human Pancreatic and Duodenal Homeobox 1 antibody for ELISA
Epitope
AA 186-215, C-Term
29
26
25
25
17
13
6
5
4
4
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human
191
41
30
4
2
2
2
1
1
1
Host
Rabbit
170
33
4
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
11
11
11
10
10
10
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
131
120
64
37
21
15
10
9
6
5
3
1
1
1
1
Supplier
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Immunogen This IPF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 186-215 AA from the C-terminal region of human IPF.
Clone RB10579
Isotype Ig
Specificity This IPF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 193~223 amino acids from the C-terminal region of human IPF.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name IPF (PDX1 Antibody Abstract)
Background IPF is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. This nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).
Synonyms: Pancreas/duodenum homeobox protein 1, PDX-1, Insulin promoter factor 1, IPF-1, Islet/duodenum homeobox-1, IDX-1, Somatostatin-transactivating factor 1, STF-1, Insulin upstream factor 1, IUF-1, Glucose-sensitive factor, GSF, PDX1, IPF1
Molecular Weight 30771 DA
Gene ID 3651
UniProt P52945
Research Area Stem Cells, Transcription Factors, Signaling, Metabolism, Cell Structure
Pathways Nuclear Receptor Transcription Pathway
Application Notes WB = 1:1000, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Pancreatic and Duodenal Homeobox 1 (PDX1) (AA 186-215), (C-Term) antibody (ABIN392141) Western blot analysis of anti-IPF Antibody (C-term) (ABIN392141) in HepG2 cell line l...
Background publications Ma, Chen, Wang et al.: "Pancreatic duodenal homeobox-1 (PDX1) functions as a tumor suppressor in gastric cancer." in: Carcinogenesis, Vol. 29, Issue 7, pp. 1327-33, 2008 (PubMed).

Watada, Kajimoto, Kaneto et al.: "Involvement of the homeodomain-containing transcription factor PDX-1 in islet amyloid polypeptide gene transcription." in: Biochemical and biophysical research communications, Vol. 229, Issue 3, pp. 746-51, 1997 (PubMed).