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PDX1 antibody (AA 1-30)

PDX1 Reactivity: Human IF, IHC, ELISA, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3032144
$578.58
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  • Target See all PDX1 Antibodies
    PDX1 (Pancreatic and Duodenal Homeobox 1 (PDX1))
    Binding Specificity
    • 25
    • 15
    • 15
    • 11
    • 9
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-30
    Reactivity
    • 131
    • 46
    • 35
    • 15
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 144
    • 8
    • 2
    Rabbit
    Clonality
    • 138
    • 16
    Polyclonal
    Conjugate
    • 63
    • 13
    • 10
    • 9
    • 8
    • 8
    • 8
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    This PDX1 antibody is un-conjugated
    Application
    • 85
    • 77
    • 41
    • 25
    • 17
    • 14
    • 14
    • 11
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Immunofluorescence (IF), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
    Cross-Reactivity (Details)
    Expected species reactivity: Mouse, Rat
    Purification
    Antigen affinity purified
    Immunogen
    A portion of amino acids 1-30 from the human protein was used as the immunogen for this PDX1 antibody.
    Isotype
    Ig Fraction
  • Application Notes
    Titration of the PDX1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Immunofluorescence: 1:100,Western blot: 1:1000,IHC (Paraffin): 1:10-1:50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Aliquot the PDX1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    PDX1 (Pancreatic and Duodenal Homeobox 1 (PDX1))
    Alternative Name
    PDX1 (PDX1 Products)
    Synonyms
    GSF antibody, IDX-1 antibody, IPF1 antibody, IUF1 antibody, MODY4 antibody, PDX-1 antibody, STF-1 antibody, ipf1 antibody, PDX1 antibody, IPF-1 antibody, Ipf1 antibody, Mody4 antibody, pdx-1 antibody, Idx1 antibody, Stf1 antibody, zgc:100874 antibody, XlHbox-8 antibody, xlhbox8 antibody, pancreatic and duodenal homeobox 1 antibody, pancreatic and duodenal homeobox 1 S homeolog antibody, PDX1 antibody, pdx1 antibody, Pdx1 antibody, pdx1.S antibody
    Background
    PDX1, located in the mitochondrial matrix, is required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex. Eukaryotic pyruvate dehydrogenase complexes are organized about a core consisting of the oligomeric dihydrolipoamide acetyl-transferase, around which are arranged multiple copies of pyruvate dehydrogenase, dihydrolipoamide dehydrogenase and protein X bound by noncovalent bonds. Defects in PDHX are a cause of lacticacidemia. PDX1 belongs to the 2-oxoacid dehydrogenase family and contains 1 lipoyl-binding domain.
    UniProt
    O00330
    Pathways
    Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Hormone Transport, Carbohydrate Homeostasis, Chromatin Binding, Maintenance of Protein Location
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