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Spectrin alpha Chain, Brain (SPTAN1) (C-Term), (AA 186-215) antibody

Details for Product No. ABIN392141
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Antigen
Synonyms im:7157190, wu:fa20e05, wu:fb33g08, wu:fk32a10, zgc:112229, 2610027H02Rik, Spna-2, Spna2, EIEE5, NEAS, SPTA2, A2a, IPF, SPECA
Epitope
C-Term, AA 186-215
(5), (4), (4), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(58), (27), (26), (16), (13), (10), (2), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(68), (13), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(6), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunofluorescence (IF)
(70), (39), (27), (27), (26), (17), (15), (10), (4), (2), (1), (1), (1)
Pubmed 2 references available
Quantity 400 µL
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Catalog No. ABIN392141
238.50 $
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Immunogen This IPF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 186-215 AA from the C-terminal region of human IPF.
Clone RB10579
Isotype Ig
Specificity This IPF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 193~223 amino acids from the C-terminal region of human IPF.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name IPF
Background IPF is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. This nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).
Synonyms: Pancreas/duodenum homeobox protein 1, PDX-1, Insulin promoter factor 1, IPF-1, Islet/duodenum homeobox-1, IDX-1, Somatostatin-transactivating factor 1, STF-1, Insulin upstream factor 1, IUF-1, Glucose-sensitive factor, GSF, PDX1, IPF1
Molecular Weight 30771 DA
Gene ID 3651
UniProt P52945
Research Area Stem Cells, Transcription Factors, Signaling, Metabolism, Cell Structure
Application Notes WB = 1:1000, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Spectrin alpha Chain, Brain (SPTAN1) (C-Term), (AA 186-215) antibody Western blot analysis of anti-IPF Antibody (C-term) (ABIN392141) in HepG2 cell line lysates (35 µg/lane). IPF(arrow) was detected using the purified polyclonal antibody (1:60dilution).
Background publications Watada, Kajimoto, Kaneto et al.: "Involvement of the homeodomain-containing transcription factor PDX-1 in islet amyloid polypeptide gene transcription." in: Biochemical and biophysical research communications, Vol. 229, Issue 3, pp. 746-51, 1997 (PubMed).

Ma, Chen, Wang et al.: "Pancreatic duodenal homeobox-1 (PDX1) functions as a tumor suppressor in gastric cancer." in: Carcinogenesis, Vol. 29, Issue 7, pp. 1327-33, 2008 (PubMed).

Validation Images
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