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Activin Receptor Type I (ACRV1) (AA 132-162), (Arg147), (Center) antibody

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Synonyms ALK2, ActR-I, ActRIA, Acvr, Acvrlk2, Alk-2, Alk8, D330013D15Rik, SKR1, Tsk7L, ACTRI, ACVR1A, ACVRLK2, FOP, TSRI, ActR-IA
AA 132-162, Arg147, Center
(59), (40), (20), (15), (15), (14), (14), (8), (4), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Human, Mouse (Murine)
(139), (43), (12), (7), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
(122), (23), (5), (1)
Clonality (Clone)
Polyclonal ()
(13), (9), (7), (7), (7), (7), (2), (1)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(131), (92), (63), (25), (5), (5), (2), (1)
Pubmed 4 references available
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Quantity 400 μL
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Availability Will be delivered in 2 to 4 Business Days
Immunogen This Activin Receptor Type IA (ACVR1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 132-162 AA from the Central region of human Activin Receptor Type IA (ACVR1).
Clone RB03507-03508
Isotype Ig
Specificity This ACVR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140~169 amino acids from the center region of human ACVR1.
Predicted Reactivity Cow (Bovine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name Activin Receptor Type IA (ACVR1) (ACRV1 Antibody Abstract)
Background Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1 (activin A type I receptor) signals a particular transcriptional response in concert with activin type II receptors.
Synonyms: Activin receptor type I, ACTR-I, Serine/threonine-protein kinase receptor R1, SKR1, Activin receptor-like kinase 2, ALK-2, TGF-B superfamily receptor type I, TSR-I, ACVRLK2
Molecular Weight 57153 DA
Gene ID 90
UniProt Q04771
Research Area Phospho-specific antibodies, Protein Modifications, Cell Structure, Cell Cycle, Transcription Factors, Signaling
Application Notes WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Activin Receptor Type I (ACRV1) (AA 132-162), (Arg147), (Center) antibody (ABIN392240) The anti-ACVR1 Pab (ABIN392240) is used in Western blot to detect ACVR1 in HeLa cell ...
Immunohistochemistry (IHC) image for anti-Activin Receptor Type I (ACRV1) (AA 132-162), (Arg147), (Center) antibody (ABIN392240) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Western Blotting (WB) image for anti-Activin Receptor Type I (ACRV1) (AA 132-162), (Arg147), (Center) antibody (ABIN392240) Western blot analysis of ACVR1 (arrow) using rabbit polyclonal ACVR1 Antibody (R147) ...
Product cited in: Mitu, Wang, Hirschberg: "BMP7 is a podocyte survival factor and rescues podocytes from diabetic injury." in: American journal of physiology. Renal physiology, Vol. 293, Issue 5, pp. F1641-8, 2007 (PubMed).

Weber, Teresi, Broelsch et al.: "A limited set of human MicroRNA is deregulated in follicular thyroid carcinoma." in: The Journal of clinical endocrinology and metabolism, Vol. 91, Issue 9, pp. 3584-91, 2006 (PubMed).

Background publications ten Dijke, Ichijo, Franzén et al.: "Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity." in: Oncogene, Vol. 8, Issue 10, pp. 2879-87, 1993 (PubMed).

Matsuzaki, Xu, Wang et al.: "A widely expressed transmembrane serine/threonine kinase that does not bind activin, inhibin, transforming growth factor beta, or bone morphogenic factor." in: The Journal of biological chemistry, Vol. 268, Issue 17, pp. 12719-23, 1993 (PubMed).

Catalog No. ABIN392240
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