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Activin Receptor Type I (ACRV1) (AA 132-162), (Arg147), (Center) antibody

Details for Product No. ABIN392240, Supplier: Log in to see
Antigen
  • ALK2
  • ActR-I
  • ActRIA
  • Acvr
  • Acvrlk2
  • Alk-2
  • Alk8
  • D330013D15Rik
  • SKR1
  • Tsk7L
  • ACTRI
  • ACVR1A
  • ACVRLK2
  • FOP
  • TSRI
  • ActR-IA
Epitope
AA 132-162, Arg147, Center
58
40
20
15
15
14
12
8
4
4
4
3
3
3
2
2
2
2
2
2
2
2
1
1
1
Reactivity
Human, Mouse (Murine)
136
42
12
7
4
2
2
2
1
1
1
1
1
1
1
1
Host
Rabbit
119
22
5
1
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
13
9
7
7
7
7
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
127
88
61
22
3
3
2
1
Supplier
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Immunogen This Activin Receptor Type IA (ACVR1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 132-162 AA from the Central region of human Activin Receptor Type IA (ACVR1).
Clone RB03507-03508
Isotype Ig
Specificity This ACVR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140~169 amino acids from the center region of human ACVR1.
Predicted Reactivity Cow (Bovine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name Activin Receptor Type IA (ACVR1) (ACRV1 Antibody Abstract)
Background Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1 (activin A type I receptor) signals a particular transcriptional response in concert with activin type II receptors.
Synonyms: Activin receptor type I, ACTR-I, Serine/threonine-protein kinase receptor R1, SKR1, Activin receptor-like kinase 2, ALK-2, TGF-B superfamily receptor type I, TSR-I, ACVRLK2
Molecular Weight 57153 DA
Gene ID 90
UniProt Q04771
Research Area Phospho-specific antibodies, Protein Modifications, Cell Structure, Cell Cycle, Transcription Factors, Signaling
Pathways
Application Notes WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Activin Receptor Type I (ACRV1) (AA 132-162), (Arg147), (Center) antibody (ABIN392240) The anti-ACVR1 Pab (ABIN392240) is used in Western blot to detect ACVR1 in HeLa cell ...
Immunohistochemistry (IHC) image for anti-Activin Receptor Type I (ACRV1) (AA 132-162), (Arg147), (Center) antibody (ABIN392240) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Western Blotting (WB) image for anti-Activin Receptor Type I (ACRV1) (AA 132-162), (Arg147), (Center) antibody (ABIN392240) Western blot analysis of ACVR1 (arrow) using rabbit polyclonal ACVR1 Antibody (R147) ...
Product cited in: Mitu, Wang, Hirschberg: "BMP7 is a podocyte survival factor and rescues podocytes from diabetic injury." in: American journal of physiology. Renal physiology, Vol. 293, Issue 5, pp. F1641-8, 2007 (PubMed).

Weber, Teresi, Broelsch et al.: "A limited set of human MicroRNA is deregulated in follicular thyroid carcinoma." in: The Journal of clinical endocrinology and metabolism, Vol. 91, Issue 9, pp. 3584-91, 2006 (PubMed).

Background publications ten Dijke, Ichijo, Franzén et al.: "Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity." in: Oncogene, Vol. 8, Issue 10, pp. 2879-87, 1993 (PubMed).

Matsuzaki, Xu, Wang et al.: "A widely expressed transmembrane serine/threonine kinase that does not bind activin, inhibin, transforming growth factor beta, or bone morphogenic factor." in: The Journal of biological chemistry, Vol. 268, Issue 17, pp. 12719-23, 1993 (PubMed).