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Activin A Receptor Type II-Like 1 (ACVRL1) (AA 38-68), (N-Term) antibody

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Synonyms ACVRL1, vgb, alk1, zehn1109, hm:zehn1109, ACVRLK1, ALK-1, ALK1, HHT, HHT2, ORW2, SKR3, TSR-I, R-3, R3, SETHKIR, AI115505, AI427544, Acvrlk1, Alk1
AA 38-68, N-Term
(36), (23), (13), (11), (9), (6), (6), (5), (4), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Human, Mouse (Murine)
(127), (34), (27), (3), (2), (2)
(94), (18), (15), (1)
Clonality (Clone)
Polyclonal ()
(6), (6), (6), (5), (5), (5), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(101), (71), (47), (20), (20), (11), (9), (5), (2), (1), (1), (1)
Pubmed 5 references available
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Quantity 400 μL
Shipping to United States ( )
Availability Will be delivered in 2 to 4 Business Days
Immunogen This ACVRL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-68 AA from the N-terminal region of human ACVRL1.
Clone RB03736
Isotype Ig
Specificity This ACVRL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46~76 amino acids from the N-terminal region of human ACVRL1.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name ACVRL1 (ACVRL1 Antibody Abstract)
Background ACVRL1 is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. This protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.
Synonyms: SKR3, Activin receptor-like kinase 1, ALK-1, TGF-B superfamily receptor type I, TSR-I
Molecular Weight 56124 DA
Gene ID 94
UniProt P37023
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Application Notes WB = 1:1000, FACS = 1:10-50, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Activin A Receptor Type II-Like 1 (ACVRL1) (AA 38-68), (N-Term) antibody (ABIN392241) Western blot of ACVRL1 Pab (ABIN392241). TOP LEFT: Mouse heart tissue lysate.
Western Blotting (WB) image for anti-Activin A Receptor Type II-Like 1 (ACVRL1) (AA 38-68), (N-Term) antibody (ABIN392241) Western blot analysis of ACVRL1 (arrow) using rabbit polyclonal ACVRL1 Antibody (N-te...
Image no. 3 for anti-Activin A Receptor Type II-Like 1 (ACVRL1) (AA 38-68), (N-Term) antibody (ABIN392241) human chondrocytes (C28/I2 cells), transfected with empty vector (lane 1, 3) or ACVRL...
Product cited in: Antonov, Antonova, Fujii et al.: "Regulation of endothelial barrier function by TGF-? type I receptor ALK5: potential role of contractile mechanisms and heat shock protein 90." in: Journal of cellular physiology, Vol. 227, Issue 2, pp. 759-71, 2011 (PubMed).

Finnson, Parker, ten Dijke et al.: "ALK1 opposes ALK5/Smad3 signaling and expression of extracellular matrix components in human chondrocytes." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 23, Issue 6, pp. 896-906, 2008 (PubMed).

Yu, Pisitkun, Wang et al.: "LC-MS/MS analysis of apical and basolateral plasma membranes of rat renal collecting duct cells." in: Molecular & cellular proteomics : MCP, Vol. 5, Issue 11, pp. 2131-45, 2006 (PubMed).

Background publications Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Attisano, Cárcamo, Ventura et al.: "Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors." in: Cell, Vol. 75, Issue 4, pp. 671-80, 1993 (PubMed).

Catalog No. ABIN392241
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