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Activin A Receptor Type II-Like 1 (ACVRL1) (AA 38-68), (N-Term) antibody

Details for Product No. ABIN392241, Supplier: Log in to see
Antigen
  • ACVRL1
  • vgb
  • alk1
  • zehn1109
  • hm:zehn1109
  • ACVRLK1
  • ALK-1
  • ALK1
  • HHT
  • HHT2
  • ORW2
  • SKR3
  • TSR-I
  • R-3
  • R3
  • SETHKIR
  • AI115505
  • AI427544
  • Acvrlk1
  • Alk1
Epitope
AA 38-68, N-Term
36
23
13
11
9
6
6
5
4
2
2
2
2
1
1
1
1
Reactivity
Human, Mouse (Murine)
123
34
27
3
2
2
Host
Rabbit
92
16
15
1
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
6
6
6
5
5
5
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
98
69
47
20
20
11
9
5
2
1
1
1
Supplier
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Immunogen This ACVRL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-68 AA from the N-terminal region of human ACVRL1.
Clone RB03736
Isotype Ig
Specificity This ACVRL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46~76 amino acids from the N-terminal region of human ACVRL1.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name ACVRL1 (ACVRL1 Antibody Abstract)
Background ACVRL1 is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. This protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.
Synonyms: SKR3, Activin receptor-like kinase 1, ALK-1, TGF-B superfamily receptor type I, TSR-I
Molecular Weight 56124 DA
Gene ID 94
UniProt P37023
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Pathways
Application Notes WB = 1:1000, FACS = 1:10-50, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Activin A Receptor Type II-Like 1 (ACVRL1) (AA 38-68), (N-Term) antibody (ABIN392241) Western blot of ACVRL1 Pab (ABIN392241). TOP LEFT: Mouse heart tissue lysate.
Western Blotting (WB) image for anti-Activin A Receptor Type II-Like 1 (ACVRL1) (AA 38-68), (N-Term) antibody (ABIN392241) Western blot analysis of ACVRL1 (arrow) using rabbit polyclonal ACVRL1 Antibody (N-te...
 image for anti-Activin A Receptor Type II-Like 1 (ACVRL1) (AA 38-68), (N-Term) antibody (ABIN392241) human chondrocytes (C28/I2 cells), transfected with empty vector (lane 1, 3) or ACVRL...
Product cited in: Antonov, Antonova, Fujii et al.: "Regulation of endothelial barrier function by TGF-? type I receptor ALK5: potential role of contractile mechanisms and heat shock protein 90." in: Journal of cellular physiology, Vol. 227, Issue 2, pp. 759-71, 2011 (PubMed).

Finnson, Parker, ten Dijke et al.: "ALK1 opposes ALK5/Smad3 signaling and expression of extracellular matrix components in human chondrocytes." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 23, Issue 6, pp. 896-906, 2008 (PubMed).

Yu, Pisitkun, Wang et al.: "LC-MS/MS analysis of apical and basolateral plasma membranes of rat renal collecting duct cells." in: Molecular & cellular proteomics : MCP, Vol. 5, Issue 11, pp. 2131-45, 2006 (PubMed).

Background publications Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Attisano, Cárcamo, Ventura et al.: "Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors." in: Cell, Vol. 75, Issue 4, pp. 671-80, 1993 (PubMed).