ACVRL1 antibody

Catalog No. ABIN7183058

This Rabbit Polyclonal antibody specifically detects ACVRL1 in WB, ELISA, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for ACVRL1 antibody (ABIN7183058)

Target: ACVRL1 (Activin A Receptor Type II-Like 1 (ACVRL1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ACVRL1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-ACVRL1 Antibody

Purpose: ACVRL1 Antibody

Cross-Reactivity: Mouse, Rat

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from internal of Human ACVL1.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ACVRL1

Target: ACVRL1 (Activin A Receptor Type II-Like 1 (ACVRL1))

Alternative Name: ACVRL1

Background:

Background: Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.

ten Dijke P., Oncogene 8:2879-2887(1993).
Attisano L., Cell 75:671-680(1993).
Berg J.N., Am. J. Hum. Genet. 61:60-67(1997).

Aliases: Activin A receptor antibody, Activin A receptor type II like 1 antibody, Activin A receptor, type II like kinase 1 antibody, Activin receptor like kinase 1 antibody, Activin receptor-like kinase 1 antibody, ACVL1_HUMAN antibody, ACVRL1 antibody, ACVRLK1 antibody, ALK-1 antibody, ALK1 antibody, HHT antibody, HHT2 antibody, ORW2 antibody, Osler Rendu Weber syndrome 2 antibody, Serine/threonine protein kinase receptor R3 antibody, Serine/threonine-protein kinase receptor R3 antibody, SKR3 antibody, TGF B superfamily receptor type I antibody, TGF-B superfamily receptor type I antibody, TSR-I antibody, TSR1 antibody

UniProt: P37023