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COP9 Constitutive Photomorphogenic Homolog Subunit 3 (Arabidopsis) (COPS3) (AA 98-130), (Center) antibody

Details for Product No. ABIN392341
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Antigen
Epitope
AA 98-130, Center
(8), (3), (3), (2), (2), (1), (1), (1), (1)
Reactivity
Human
(34), (12), (8), (1), (1)
Host
Rabbit
(21), (11), (3)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(34), (18), (14), (12), (5), (4)
Pubmed 3 references available
Quantity 400 µL
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Catalog No. ABIN392341
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Immunogen This COPS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 98-130 AA from the Central region of human COPS3.
Clone RB17614
Isotype Ig
Specificity This COPS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107~136 amino acids from the Center region of human COPS3.
Predicted Reactivity Mouse (Murine),Monkey,Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name COPS3
Background COPS3 possesses kinase activity that phosphorylates regulators involved in signal transduction. This protein phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation.
Synonyms: COP9 signalosome complex subunit 3, JAB1-containing signalosome subunit 3, CSN3
Molecular Weight 47873 DA
Gene ID 8533
UniProt Q9UNS2
Research Area Phospho-specific antibodies, Stem Cells, Cell Signaling, Protein Modifications, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-COP9 Constitutive Photomorphogenic Homolog Subunit 3 (Arabidopsis) (COPS3) (AA 98-130), (Center) antibody Western blot analysis of COPS3 Antibody (Center) (ABIN392341) in Jurkat, 293 cell line lysates (35 µg/lane). COPS3 (arrow) was detected using the purified polyclonal antibody.
anti-COP9 Constitutive Photomorphogenic Homolog Subunit 3 (Arabidopsis) (COPS3) (AA 98-130), (Center) antibody (2) Western blot analysis of COPS3 (arrow) using rabbit polyclonal COPS3 Antibody (Center) (ABIN392341). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the COPS3 gene.
Background publications Potocki, Chen, Lupski: "Subunit 3 of the COP9 signal transduction complex is conserved from plants to humans and maps within the smith-magenis syndrome critical region in 17p11.2." in: Genomics, Vol. 57, Issue 1, pp. 180-2, 1999 (PubMed).

Bech-Otschir, Kraft, Huang et al.: "COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system." in: The EMBO journal, Vol. 20, Issue 7, pp. 1630-9, 2001 (PubMed).

Henriksen, Aagesen, Maelandsmo et al.: "Amplification and overexpression of COPS3 in osteosarcomas potentially target TP53 for proteasome-mediated degradation." in: Oncogene, Vol. 22, Issue 34, pp. 5358-61, 2003 (PubMed).

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