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Details for Product No. ABIN392341

COP9 Constitutive Photomorphogenic Homolog Subunit 3 (Arabidopsis) (COPS3) (AA 98-130), (Center) antibody

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Antigen
Synonyms
CSN3, SGN3, Csn3, Sgn3, wu:fc32a02, wu:fk59f01, zgc:111903, zgc:55643, zgc:77615, csn3, CONSTITUTIVE PHOTOMORPHOGENIC 13, COP9 SIGNALOSOME SUBUNIT 3, F18O22.40, F18O22_40, FUS11, FUSCA 11, CG18332, CH ... show more
Epitope
»Alternatives AA 98-130, Center
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Application
»Alternatives Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN392341
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This COPS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 98-130 AA from the Central region of human COPS3.
Clone RB17614
Isotype Ig
Specificity This COPS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107~136 amino acids from the Center region of human COPS3.
Predicted Reactivity Mouse (Murine),Monkey,Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name COPS3
Background COPS3 possesses kinase activity that phosphorylates regulators involved in signal transduction. This protein phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation.
Synonyms: COP9 signalosome complex subunit 3, JAB1-containing signalosome subunit 3, CSN3
Molecular Weight 47873 DA
Gene ID 8533
UniProt Q9UNS2
Research Area Phospho-specific antibodies, Stem Cells, Cell Signaling, Protein Modifications, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Potocki, Chen, Lupski: "Subunit 3 of the COP9 signal transduction complex is conserved from plants to humans and maps within the smith-magenis syndrome critical region in 17p11.2." in: Genomics, Vol. 57, Issue 1, pp. 180-2, 1999 (PubMed).

Bech-Otschir, Kraft, Huang et al.: "COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system." in: The EMBO journal, Vol. 20, Issue 7, pp. 1630-9, 2001 (PubMed).

Henriksen, Aagesen, Maelandsmo et al.: "Amplification and overexpression of COPS3 in osteosarcomas potentially target TP53 for proteasome-mediated degradation." in: Oncogene, Vol. 22, Issue 34, pp. 5358-61, 2003 (PubMed).

Alternatives for antigen "COP9 Constitutive Photomorphogenic Homolog Subunit 3 (Arabidopsis) (COPS3)", type "Antibodies"
Hosts (19), (5), (2)
Reactivities (27), (13), (10), (3), (3), (2), (2), (2), (2), (2), (1)
Applications (27), (13), (9), (4), (3), (2), (2), (2)
Epitopes (4), (2), (2), (1), (1), (1), (1)
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