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Details for Product No. ABIN392424

Mitogen-Activated Protein Kinase Kinase Kinase 10 (MAP3K10) (C-Term), (AA 628-659) antibody

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Antigen
Synonyms MST, MLK2, MEKK10, Mlk2, BC028668, BC046514, mlk2, xmlk2
Epitope
»Alternatives C-Term, AA 628-659
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 4 references available
Catalog no. ABIN392424
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This MLK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 628-659 AA from the C-terminal region of human MLK2.
Clone RB0986
Isotype Ig
Specificity This MLK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 636~666 amino acids from the C-terminal region of human MLK2.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name MLK2
Background MLK2 is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.
Synonyms: Mixed lineage kinase 2, Mitogen-activated protein kinase kinase kinase 10, Protein kinase MST
Molecular Weight 103623 DA
Gene ID 4294
UniProt Q02779
Research Area Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Cycle, Neurology, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Katoh, Hirai, Sugimura et al.: "Cloning and characterization of MST, a novel (putative) serine/threonine kinase with SH3 domain." in: Oncogene, Vol. 10, Issue 7, pp. 1447-51, 1995 (PubMed).

Dorow, Devereux, Dietzsch et al.: "Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domains." in: European journal of biochemistry / FEBS, Vol. 213, Issue 2, pp. 701-10, 1993 (PubMed).

Dorow, Devereux, Tu et al.: "Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2." in: European journal of biochemistry / FEBS, Vol. 234, Issue 2, pp. 492-500, 1996 (PubMed).

Humphrey, Newcomb, Yu et al.: "Mixed-Lineage kinase-3 stabilizes and functionally cooperates with tribbles 3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cells." in: The Journal of biological chemistry, 2010 (PubMed).

Alternatives for antigen "Mitogen-Activated Protein Kinase Kinase Kinase 10 (MAP3K10)", type "Antibodies"
Hosts (29)
Reactivities (29), (18), (11), (11), (11), (11), (11)
Applications (15), (11), (9), (7), (7)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (5), (3), (3), (1), (1)
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