Nuclear Receptor Subfamily 2, Group C, Member 2 (NR2C2) (C-Term), (AA 574-606) antibody

Details for Product No. ABIN392466
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Antigen
Synonyms TR4, TAK1, TR2R1, hTAK1, Tr4, im:6911408, gb:dq017625, mKIAA4145, Tak1, B430101B05, C87327
Epitope
C-Term, AA 574-606
(36), (24), (16), (13), (12), (12), (4), (2), (2), (2), (2), (2), (1)
Reactivity
Human
(127), (110), (109), (75), (61), (48), (15), (2), (2), (1), (1)
Host
Rabbit
(128), (8)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(82), (60), (54), (26), (5), (2), (2), (1), (1), (1)
Pubmed 4 references available
Catalog no. ABIN392466
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This TAK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 574-606 AA from the C-terminal region of human TAK1.
Clone RB0993
Isotype Ig
Specificity This TAK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 577~606 amino acids from the C-terminal region of human TAK1.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name TAK1
Background TAK1 is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2, this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses.
Synonyms: M3K7, Mitogen-activated protein kinase kinase kinase 7, Transforming growth factor-beta-activated kinase 1, TGF-beta-activated kinase 1, MAP3K7
Molecular Weight 67196 DA
Gene ID 6885
UniProt O43318
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Transcription Factors, Signaling, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 1.29 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Nuclear Receptor Subfamily 2, Group C, Member 2 (NR2C2) (C-Term), (AA 574-606) antibody Western blot analysis of anti-TAK1 Pab (ABIN392466) in HL60 cell lysate. TAK1 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
anti-Nuclear Receptor Subfamily 2, Group C, Member 2 (NR2C2) (C-Term), (AA 574-606) antibody (2) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
Background publications Edlund, Bu, Schuster et al.: "Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3." in: Molecular biology of the cell, Vol. 14, Issue 2, pp. 529-44, 2003 (PubMed).

Sakurai, Suzuki, Kawasaki et al.: "Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway." in: The Journal of biological chemistry, Vol. 278, Issue 38, pp. 36916-23, 2003 (PubMed).

Ono, Ohtomo, Ninomiya-Tsuji et al.: "A dominant negative TAK1 inhibits cellular fibrotic responses induced by TGF-beta." in: Biochemical and biophysical research communications, Vol. 307, Issue 2, pp. 332-7, 2003 (PubMed).

Cheung, Campbell, Nebreda et al.: "Feedback control of the protein kinase TAK1 by SAPK2a/p38alpha." in: The EMBO journal, Vol. 22, Issue 21, pp. 5793-805, 2003 (PubMed).

Hosts (128), (8)
Reactivities (127), (110), (109), (75), (61), (48), (15), (2), (2), (1), (1)
Applications (82), (60), (54), (26), (5), (2), (2), (1), (1), (1)
Conjugates (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6)
Epitopes (36), (24), (16), (13), (12), (12), (4), (2), (2), (2), (2), (2), (1)
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