TR4 antibody (AA 62-356)

Catalog No. ABIN7193400

Product Details anti-TR4 Antibody

Target: TR4 (NR2C2) (Nuclear Receptor Subfamily 2, Group C, Member 2 (NR2C2))

Binding Specificity: AA 62-356

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TR4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Purification: purified

Immunogen: Purified recombinant fragment of human NR2C2 (AA: 62-356) expressed in E. coli.

Clone: 8F2E8

Isotype: IgG1

Application Details

Application Notes: WB:1:500 - 1:2000, FCM:1:200 - 1:400, ELISA:1:10000,

Restrictions: For Research Use only

Handling

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

Target Details for TR4

Target: TR4 (NR2C2) (Nuclear Receptor Subfamily 2, Group C, Member 2 (NR2C2))

Alternative Name: NR2C2 (NR2C2 Products)

Synonyms: TAK1 antibody, TR2R1 antibody, TR4 antibody, hTAK1 antibody, Tr4 antibody, gb:dq017625 antibody, im:6911408 antibody, mKIAA4145 antibody, nuclear receptor subfamily 2 group C member 2 antibody, nuclear receptor subfamily 2, group C, member 2 antibody, NR2C2 antibody, Nr2c2 antibody, nr2c2 antibody

Background:

Description: This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

Aliases: TR4, TAK1

Molecular Weight: 65.4 kDa

Gene ID: 7182

Pathways: TCR Signaling, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Toll-Like Receptors Cascades