TR4 antibody (AA 62-356)

Catalog No. ABIN7193400

The Mouse Monoclonal anti-TR4 antibody (Clone 8F2E8) (ABIN7193400) specifically detects TR4 in ELISA and FACS. The antibody is reactive with Human samples.

Quick Overview for TR4 antibody (AA 62-356) (ABIN7193400)

Target: TR4 (NR2C2) (Nuclear Receptor Subfamily 2, Group C, Member 2 (NR2C2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TR4 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS)

Clone: 8F2E8

Product Details anti-TR4 Antibody

Binding Specificity: AA 62-356

Purpose: NR2C2 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human NR2C2 (AA: 62-356) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for TR4

Target: TR4 (NR2C2) (Nuclear Receptor Subfamily 2, Group C, Member 2 (NR2C2))

Alternative Name: NR2C2

Background:

This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

Molecular Weight: 65.4 kDa

Gene ID: 7182

UniProt: P49116

Pathways: TCR Signaling, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Toll-Like Receptors Cascades