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RAD23 Homolog B (S. Cerevisiae) (RAD23B) (AA 163-176) antibody

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Synonyms MGC107846, HHR23B, HR23B, P58, zgc:65951, 0610007D13Rik, AV001138, mHR23B, p58
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AA 163-176
(26), (16), (16), (13), (9), (8), (4), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Dog (Canine), Chimpanzee, Human, Yeast (Saccharomyces cerevisiae)
(118), (36), (33), (3), (3), (3), (2), (1), (1)
(72), (36), (10)
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Western Blotting (WB)
(96), (40), (20), (19), (18), (11), (8), (4), (3), (2), (1), (1), (1)
Pubmed 7 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Synthetic peptide corresponding aa 163-176 of human HR23B protein
Isotype IgG
Specificity Reactivity occurs against Human HR23B protein. Cross reactivity with HR23B protein from Mouse and Rat may also occur as sequence homology varies by one amino acid residue in this sequence by BLAST analysis. Reactivity with HR23B protein from other sources is not known.
Cross-Reactivity (Details) Species reactivity (expected):Canine, Chimpanzee, S.cerevisiae.
Species reactivity (tested):Human.
Purification Immunoaffinity Chromatography using the immunizing peptide after immobilization to a solid phase
Alternative Name RAD23B (RAD23B Antibody Abstract)
Background HR23B (also known as UV excision repair protein RAD23 homolog B, XP-C repair complementing complex 58 kDa protein and p58) is one of two human homologs of Saccharomyces cerevisiae Rad23 (hHR23A and hHR23B), a protein involved in nucleotide excision repair (NER). This protein was shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, as well as with ubiquitin protein ligase E6AP, and thus suggests that this protein may be involved in the ubiquitin mediated proteolytic pathway in cells.Synonyms: HR23B, UV excision repair protein RAD23 homolog B, XP-C repair-complementing complex 58 kDa protein
Gene ID 5887
NCBI Accession NP_002865
UniProt P54727
Pathways DNA Damage Repair
Application Notes ELISA: 1/2000 - 1/10000. Western Blot: 1/500 - 1/2000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.1 mg/mL (by UV absorbance at 280 nm)
Buffer 0.02 M Potassium Phosphate, 0.12 M Sodium Chloride, pH 7.2, 0.01 % (w/v) Sodium Azide, None
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Supplier Images
 image for anti-RAD23 Homolog B (S. Cerevisiae) (RAD23B) (AA 163-176) antibody (ABIN401177) anti-RAD23 Homolog B (S. Cerevisiae) (RAD23B) (AA 163-176) antibody
 image for anti-RAD23 Homolog B (S. Cerevisiae) (RAD23B) (AA 163-176) antibody (ABIN401177) anti-RAD23 Homolog B (S. Cerevisiae) (RAD23B) (AA 163-176) antibody (Image 2)
Background publications Huang, Wang, Xu et al.: "Expression of a novel RAD23B mRNA splice variant in the human testis." in: Journal of andrology, Vol. 25, Issue 3, pp. 363-8, 2004 (PubMed).

Glockzin, Ogi, Hengstermann et al.: "Involvement of the DNA repair protein hHR23 in p53 degradation." in: Molecular and cellular biology, Vol. 23, Issue 24, pp. 8960-9, 2003 (PubMed).

Fujiwara, Tenno, Sugasawa et al.: "Structure of the ubiquitin-interacting motif of S5a bound to the ubiquitin-like domain of HR23B." in: The Journal of biological chemistry, Vol. 279, Issue 6, pp. 4760-7, 2004 (PubMed).

Ng, Vermeulen, van der Horst et al.: "A novel regulation mechanism of DNA repair by damage-induced and RAD23-dependent stabilization of xeroderma pigmentosum group C protein." in: Genes & development, Vol. 17, Issue 13, pp. 1630-45, 2003 (PubMed).

Oh, Choi, Kim et al.: "Detection of epidermal growth factor receptor in the serum of patients with cervical carcinoma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 6, Issue 12, pp. 4760-3, 2001 (PubMed).

van der Spek, Eker, Rademakers et al.: "XPC and human homologs of RAD23: intracellular localization and relationship to other nucleotide excision repair complexes." in: Nucleic acids research, Vol. 24, Issue 13, pp. 2551-9, 1996 (PubMed).

van der Spek, Smit, Beverloo et al.: "Chromosomal localization of three repair genes: the xeroderma pigmentosum group C gene and two human homologs of yeast RAD23." in: Genomics, Vol. 23, Issue 3, pp. 651-8, 1995 (PubMed).

Catalog No. ABIN401177
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