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Lysosomal-Associated Membrane Protein 1 (LAMP1) antibody

Details for Product No. ABIN497981
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Antigen
Synonyms AI196048, CD107a, Lamp-1, LAMPA, LGP120, LEP100
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(132), (69), (58), (7), (7), (3), (3), (2)
Host
Rabbit
(92), (73), (31), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(22), (15), (15), (10), (3), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
(110), (87), (43), (39), (38), (32), (28), (22), (19), (10), (1), (1)
Pubmed 7 references available
Quantity 0.1 mg
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Catalog No. ABIN497981
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Immunogen LAMP1 antibody was raised against a 15 amino acid peptide from near the center of Human LAMP-1.
Isotype IgG
Specificity Recognizes CD107a/LAMP1 (Center). Species Reactivity: Tested: Human, Mouse, Rat
Purification Immunoaffinity Chromatography
Alternative Name CD107a / LAMP1
Background Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components (1,2) and is negatively regulated by TOR (Target of rapamycin) (3). A protein recently found to be involved in autophagy, LAMP-2, is a highly glycosylated protein associated with the lysosome (4,5). LAMP-1 shares much homology to LAMP-2 and is thought to have overlapping functions. Mice lacking LAMP-1 had very minor defects compared to those deficient in LAMP-2 expression (6). However, the loss of both proteins resulted in embryonic lethality (7), suggesting that each protein possesses some unique and necessary functions.
Alternate names: CD107 Antigen-like Family Member A, LAMP-1, LAMPA, LGP120, Lysosome-associated membrane glycoprotein 1
Gene ID 3916
NCBI Accession NP_005552
UniProt P11279
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes ELISA. Western blot: CD107a/LAMP1 antibody can be used for the detection of CD107a/LAMP1 at1–2 μg/ml. Despite its predicted size, LAMP-1 migrates at 110kDa in SDS-PAGE. Positive Control: EL4 Cell Lysate. Immunofluorescence. Positive Control: Human Colon Tissue Lysate. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.02% Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C. Antibodies should not be exposed to prolonged high temperatures.
Expiry Date 12 months
Background publications Chen, Murphy, Willingham et al.: "Identification of two lysosomal membrane glycoproteins." in: The Journal of cell biology, Vol. 101, Issue 1, pp. 85-95, 1985 (PubMed).

Kisen, Tessitore, Costelli et al.: "Reduced autophagic activity in primary rat hepatocellular carcinoma and ascites hepatoma cells." in: Carcinogenesis, Vol. 14, Issue 12, pp. 2501-5, 1994 (PubMed).

Andrejewski, Punnonen, Guhde et al.: "Normal lysosomal morphology and function in LAMP-1-deficient mice." in: The Journal of biological chemistry, Vol. 274, Issue 18, pp. 12692-701, 1999 (PubMed).

Tanaka, Guhde, Suter et al.: "Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice." in: Nature, Vol. 406, Issue 6798, pp. 902-6, 2000 (PubMed).

Kamada, Funakoshi, Shintani et al.: "Tor-mediated induction of autophagy via an Apg1 protein kinase complex." in: The Journal of cell biology, Vol. 150, Issue 6, pp. 1507-13, 2000 (PubMed).

Gamp, Tanaka, Lüllmann-Rauch et al.: "LIMP-2/LGP85 deficiency causes ureteric pelvic junction obstruction, deafness and peripheral neuropathy in mice." in: Human molecular genetics, Vol. 12, Issue 6, pp. 631-46, 2003 (PubMed).

Gozuacik, Kimchi: "Autophagy as a cell death and tumor suppressor mechanism." in: Oncogene, Vol. 23, Issue 16, pp. 2891-906, 2004 (PubMed).

Validation Images
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