DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) (C-Term) antibody

Details for Product No. ABIN500164
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Synonyms MGC82787, DHX58, lgp2, D11LGP2, D11lgp2e, LGP2, RLR-3, B430001I08Rik, D11Lgp2e, LPG2, Lgp2, RGD1310093
(32), (28), (15), (7), (4), (3), (3), (2), (1), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(98), (28), (28), (2), (1), (1), (1)
(78), (16), (4)
(3), (3), (3), (3), (3), (3)
Enzyme Immunoassay (EIA), Western Blotting (WB)
(95), (57), (19), (5), (5), (4), (3)
Pubmed 5 references available
Quantity 0.1 mg
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Availability Will be delivered in 6 to 8 Business Days
Immunogen LGP2 antibody was raised against a 12 amino acid peptide from near the carboxy terminus of human LGP2.
Isotype IgG
Specificity This antibody detects DHX58 at C-term.
Purification Peptide affinity chromatography
Alternative Name DHX58 (DHX58 Antibody Abstract)
Background Anti-viral innate immune responses are triggered by pathogen-associated molecular patters (such as the accumulation of intracellular nucleic acids resulting from virus infections) and represent the first line of defense against numerous infectious organisms. The Toll-like receptors (TLR) 3, 7, 8, and 9 are expressed in immune cells and function as transmembrane pattern recognition receptors to detect foreign nucleic acids. Other proteins that play similar roles, such as RIG-1 and MDA5 are members of a CARD-helicase family and are expressed in the cytoplasm. A third protein, LGP2, is similar to RIG-1 and MDA5, except for lacking a homologous CARD domain. It is thought to act as an element of negative-feedback regulation of intracellular antiviral signaling. At least four isoforms of LGP2 are known to exist.Synonyms: ATP-dependent RNA helicase DHX58, ATP-dependent helicase LGP2, D11LGP2E, DHX58, LGP2, Protein D11Lgp2 homolog
Gene ID 79132
UniProt Q96C10
Research Area Immunology, DNA/RNA
Application Notes ELISA. Western blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1,0 mg/mL
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) (C-Term) antibody (ABIN500164) Western blot analysis of LGP2 in rat kidney tissue lysate with AP30503PU-N at (A) 1 a...
Background publications Akira, Uematsu, Takeuchi: "Pathogen recognition and innate immunity." in: Cell, Vol. 124, Issue 4, pp. 783-801, 2006 (PubMed).

Andrejeva, Childs, Young et al.: "The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 49, pp. 17264-9, 2004 (PubMed).

Iwasaki, Medzhitov: "Toll-like receptor control of the adaptive immune responses." in: Nature immunology, Vol. 5, Issue 10, pp. 987-95, 2004 (PubMed).

Yoneyama, Kikuchi, Natsukawa et al.: "The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses." in: Nature immunology, Vol. 5, Issue 7, pp. 730-7, 2004 (PubMed).

Benesh, Liyanage: "Surface-embedded Green-function method for general surfaces: Application to Al(111)." in: Physical review. B, Condensed matter, Vol. 49, Issue 24, pp. 17264-17272, 1999 (PubMed).

Catalog No. ABIN500164
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