DHX58 Products
(DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58))
Categories
Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1- dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate.
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Featured DHX58 Categories
DHX58 Antibodies
High quality antibodies with extensive validation data.
DHX58 ELISA Kits
Reliable ELISA kits for a wide range of species.
DHX58 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended DHX58 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, FACS, ICC
Validations
- (4)
Cat. No.
ABIN5542450
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, FACS, ICC
Validations
- (4)
Cat. No.
ABIN5542451
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7164384
Quantity
100 μL
Datasheet
Datasheet
Recommended DHX58 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN3198476
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Chicken
Analytical Method
Validations
Cat. No.
ABIN1773426
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Sheep
Analytical Method
Validations
Cat. No.
ABIN1774650
Quantity
96 tests
Datasheet
Datasheet
Recommended DHX58 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1351580
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3092156
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3136923
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our DHX58 products
: "DDX39B interacts with the pattern recognition receptor pathway to inhibit NF-κB and sensitize to alkylating chemotherapy." in: BMC biology, Vol. 18, Issue 1, pp. 32, (2020) (PubMed).: "Cancer therapies activate RIG-I-like receptor pathway through endogenous non-coding RNAs." in: Oncotarget, Vol. 7, Issue 18, pp. 26496-515, (2018) (PubMed).
: "Comparative analysis of viral RNA signatures on different RIG-I-like receptors." in: eLife, Vol. 5, pp. e11275, (2016) (PubMed).
: "Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 2, pp. 582-7, (2007) (PubMed).
: "RNA- and virus-independent inhibition of antiviral signaling by RNA helicase LGP2." in: Journal of virology, Vol. 80, Issue 24, pp. 12332-42, (2006) (PubMed).
: "Pathogen recognition and innate immunity." in: Cell, Vol. 124, Issue 4, pp. 783-801, (2006) (PubMed).
: "The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 49, pp. 17264-9, (2004) (PubMed).
: "Toll-like receptor control of the adaptive immune responses." in: Nature immunology, Vol. 5, Issue 10, pp. 987-95, (2004) (PubMed).
Synonyms and alternative names related to DHX58
DEXH-box helicase 58 L homeolog (dhx58.L), DExH-box helicase 58 (DHX58), DExH-box helicase 58 (dhx58), probable ATP-dependent RNA helicase DHX58 (LOC100566102), DEXH (Asp-Glu-X-His) box polypeptide 58 (dhx58), DEXH (Asp-Glu-X-His) box polypeptide 58 (Dhx58), DEXH-box helicase 58 (Dhx58), B430001I08Rik, D11LGP2, D11lgp2e, D11Lgp2e, DHX58, lgp2, LGP2, Lgp2, LPG2, MGC82787, RGD1310093, RLR-3Protein level used designations for DHX58
- DEXH (Asp-Glu-X-His) box polypeptide 58
- probable ATP-dependent RNA helicase DHX58
- probable ATP-dependent RNA helicase DHX58-like
- Probable ATP-dependent RNA helicase DHX58
- RIG-I-like receptor 3
- RIG-I-like receptor LGP2
- RLR
- RNA helicase LGP2
- ortholog of mouse D11lgp2
- probable ATP-dependent helicase LGP2
- protein D11Lgp2 homolog
- RIG-I-like receptor Lgp2
- protein D11Lgp2
- ATP-dependent RNA helicase DHX58
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