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DHX58 antibody

DHX58 Reactivity: Human, Rat WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7247327
  • Target See all DHX58 Antibodies
    DHX58 (DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58))
    Reactivity
    • 42
    • 8
    • 8
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Rat
    Host
    • 29
    • 12
    • 1
    Rabbit
    Clonality
    • 32
    • 10
    Polyclonal
    Conjugate
    • 25
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This DHX58 antibody is un-conjugated
    Application
    • 35
    • 23
    • 21
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Characteristics
    Polyclonal Antibody
    Purification
    Antigen affinity purification
    Immunogen
    Fusion protein of human DHX58
    Isotype
    IgG
    Top Product
    Discover our top product DHX58 Primary Antibody
  • Application Notes
    WB 1:500-1:2000, IHC 1:50-1:100, ELISA 1:5000-1:10000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.02 mg/mL
    Buffer
    PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    DHX58 (DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58))
    Alternative Name
    DHX58 (DHX58 Products)
    Synonyms
    MGC82787 antibody, DHX58 antibody, lgp2 antibody, D11LGP2 antibody, D11lgp2e antibody, LGP2 antibody, RLR-3 antibody, B430001I08Rik antibody, D11Lgp2e antibody, LPG2 antibody, Lgp2 antibody, RGD1310093 antibody, DEXH-box helicase 58 L homeolog antibody, DExH-box helicase 58 antibody, probable ATP-dependent RNA helicase DHX58 antibody, DEXH (Asp-Glu-X-His) box polypeptide 58 antibody, DEXH-box helicase 58 antibody, dhx58.L antibody, DHX58 antibody, dhx58 antibody, LOC100566102 antibody, Dhx58 antibody
    Background
    Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate.
    Molecular Weight

    Observed_MW: Refer to figures

    Calculated_MW: 77 kDa

    UniProt
    Q96C10
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