Presenilin 1 (PSEN1) (C-Term) antibody

Details for Product No. ABIN500539
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Antigen
Synonyms pre1, psen, zfPS1, zf-PS1, ad3, fad, ps1, s182, X-PS-beta, X-PS-alpha, AD3, FAD, PS-1, PS1, S182, Ad3h
Epitope
C-Term
(35), (20), (6), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(168), (78), (53), (36), (36), (36), (24), (24), (4), (1)
Host
Rabbit
(126), (36), (12), (2), (2), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (6), (4), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1), (1)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(125), (74), (59), (40), (30), (16), (14), (6), (5), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN500539
401.50 $
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Immunogen Presenilin1 antibody was raised against a 23 amino acid peptide from near the carboxy terminus of human presenilin1.
Isotype IgG
Specificity This antibody detects Presenilin-1. It has no cross-reactivity to presenilin-2. Species Reactivity: Tested: Human, mouse, rat
Purification Peptide affinity chromatography
Alternative Name Presenilin-1
Background Presenilin1 was initially identified a marker of susceptibility to early-onset Alzheimer’s disease. In addition to PEN2, nicastrin and APH-1, Presenilin1 forms the g-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer’s disease. Like the tumor necrosis factor-a-converting enzyme (TACE) and the b-site cleavage enzyme (BACE) protease families, g-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the a and g cleavage site) or the toxic Ab amyloid peptide (from the b and g cleavage site). It is thought that accumulation of the Ab peptide is the precursor to Alzheimer’s disease. Multiple isoforms of presenilin1 are known to exist.
Alternate names: AD3, AF3, Alzheimer Disease 3, FAD, PS-1, PS1, PSEN1, PSNL1, Presenilin 1, S182
Gene ID 5663
NCBI Accession NP_000012
UniProt P49768
Research Area Alzheimer's Disease
Application Notes ELISA. Western blot: 0.5 – 1 μg/ml. Immunohistochemistry on paraffin sections. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Sherrington, Rogaev, Liang et al.: "Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease." in: Nature, Vol. 375, Issue 6534, pp. 754-60, 1995 (PubMed).

Selkoe: "The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease." in: Trends in cell biology, Vol. 8, Issue 11, pp. 447-53, 1999 (PubMed).

Weihofen, Martoglio: "Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides." in: Trends in cell biology, Vol. 13, Issue 2, pp. 71-8, 2003 (PubMed).

Periz, Fortini: "Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2." in: Journal of neuroscience research, Vol. 77, Issue 3, pp. 309-22, 2004 (PubMed).

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