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Presenilin 1 antibody (PSEN1) (C-Term)

Details for Product anti-PSEN1 Antibody No. ABIN500539, Supplier: Log in to see
Antigen
  • pre1
  • psen
  • zfPS1
  • zf-PS1
  • ad3
  • fad
  • ps1
  • s182
  • X-PS-beta
  • X-PS-alpha
  • AD3
  • FAD
  • PS-1
  • PS1
  • S182
  • Ad3h
Alternatives
anti-Human Presenilin 1 antibody for Enzyme Immunoassay
Epitope
C-Term
53
51
13
9
6
4
4
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
222
79
58
26
10
4
4
4
2
Host
Rabbit
155
40
19
4
3
2
Clonality
Polyclonal
Conjugate
This Presenilin 1 antibody is un-conjugated
8
6
6
3
3
3
3
3
3
3
3
3
3
3
3
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
157
98
82
34
33
20
14
7
4
3
3
2
2
1
1
Supplier
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Immunogen Presenilin1 antibody was raised against a 23 amino acid peptide from near the carboxy terminus of human presenilin1.
Isotype IgG
Specificity This antibody detects Presenilin-1. It has no cross-reactivity to presenilin-2.
Cross-Reactivity (Details) Species reactivity (tested):Human, mouse, rat
Purification Peptide affinity chromatography
Alternative Name Presenilin-1 (PSEN1 Antibody Abstract)
Background Presenilin1 was initially identified a marker of susceptibility to early-onset Alzheimer's disease. In addition to PEN2, nicastrin and APH-1, Presenilin1 forms the g-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease. Like the tumor necrosis factor-a-converting enzyme (TACE) and the b-site cleavage enzyme (BACE) protease families, g-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the a and g cleavage site) or the toxic Ab amyloid peptide (from the b and g cleavage site). It is thought that accumulation of the Ab peptide is the precursor to Alzheimer's disease. Multiple isoforms of presenilin1 are known to exist.Synonyms: AD3, AF3, Alzheimer Disease 3, FAD, PS-1, PS1, PSEN1, PSNL1, Presenilin 1, S182
Gene ID 5663
NCBI Accession NP_000012
UniProt P49768
Research Area Alzheimer's Disease
Pathways Notch Signaling, EGFR Signaling Pathway
Application Notes ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Presenilin 1 antibody (PSEN1) (C-Term) (ABIN500539) Immunohistochemistry of Presenilin1 in human brain tissue with this product at 2.5 μg...
Western Blotting (WB) image for anti-Presenilin 1 antibody (PSEN1) (C-Term) (ABIN500539) Western blot analysis of presenilin1 in human brain lysate with this product at (A) 0...
Background publications Periz, Fortini: "Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2." in: Journal of neuroscience research, Vol. 77, Issue 3, pp. 309-22, 2004 (PubMed).

Weihofen, Martoglio: "Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides." in: Trends in cell biology, Vol. 13, Issue 2, pp. 71-8, 2003 (PubMed).

Selkoe: "The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease." in: Trends in cell biology, Vol. 8, Issue 11, pp. 447-53, 1999 (PubMed).

Sherrington, Rogaev, Liang et al.: "Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. ..." in: Nature, Vol. 375, Issue 6534, pp. 754-60, 1995 (PubMed).