TBC1 Domain Family, Member 10C (TBC1D10C) (N-Term) antibody

Details for Product No. ABIN503788
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Antigen
Synonyms CARABIN, EPI64C, 1810062O14Rik, AI428527, RGD1311490
Epitope
N-Term
(16), (11), (3), (1)
Reactivity
Rat (Rattus), Dog (Canine), Cow (Bovine), Human
(36), (20), (3), (2), (1), (1)
Host
Rabbit
(33), (5)
Clonality
Polyclonal
Application
Western Blotting (WB)
(36), (24), (16), (6)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN503788
289.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human TBC1D10C
Sequence MAQALGEDLV QPPELQDDSS SLGSDSELSG PGPYRQADRY GFIGGSSAEP
Predicted Reactivity Human : 100 %, Dog : 90 %, Horse : 90 %, Pig : 90 %, Bovine : 80 %, Rat : 70 %
Characteristics This is a rabbit polyclonal antibody against TBC1D10C. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name TBC1D10C
Background TBC1D10C inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. TBC1D10C acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras.Carabin is an endogenous inhibitor of calcineurin (see MIM 114105) that also inhibits the Ras (see MIM 190020) signaling pathway through its intrinsic Ras GTPase-activating protein activity (Pan et al., 2007 [PubMed 17230191]).
Molecular Weight 50 kDa
Gene ID 374403
NCBI Accession NM_198517, NP_940919
UniProt Q8IV04
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 446 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-TBC1 Domain Family, Member 10C (TBC1D10C) (N-Term) antibody WB Suggested Anti-TBC1D10C Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: Jurkat cell lysate
Background publications Pan, Sun, Kardian et al.: "Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin." in: Nature, Vol. 445, Issue 7126, pp. 433-6, 2007 (PubMed).

Validation Images
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