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Carabin antibody (N-Term)

TBC1D10C Reactivity: Human, Mouse WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN499531
  • Target See all Carabin (TBC1D10C) Antibodies
    Carabin (TBC1D10C) (TBC1 Domain Family, Member 10C (TBC1D10C))
    Binding Specificity
    • 4
    • 2
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 9
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Mouse
    Host
    • 8
    • 1
    Rabbit
    Clonality
    • 9
    Polyclonal
    Conjugate
    • 9
    This Carabin antibody is un-conjugated
    Application
    • 9
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody reacts to Carabin.
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    Carabin antibody was raised against a 17 amino acid peptide from near the amino terminus of human Carabin.
    Isotype
    IgG
    Top Product
    Discover our top product TBC1D10C Primary Antibody
  • Application Notes
    ELISA. Western Blot: Carabin antibody can be used for detection of Carabin at 1 - 2 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C.
  • Target
    Carabin (TBC1D10C) (TBC1 Domain Family, Member 10C (TBC1D10C))
    Alternative Name
    Carabin (TBC1D10C Products)
    Synonyms
    CARABIN antibody, EPI64C antibody, 1810062O14Rik antibody, AI428527 antibody, RGD1311490 antibody, TBC1 domain family member 10C antibody, TBC1 domain family, member 10c antibody, TBC1 domain family, member 10C antibody, TBC1D10C antibody, Tbc1d10c antibody
    Background
    Antigen binding by the T-cell receptor (TCR) is one of the critical first steps in the immune response, triggering a cascade of signaling pathways that ultimately lead to T-cell activation. Screening a yeast two-hybrid screen of a human T-cell cDNA library with calcineurin, a protein phosphatase involved in multiple signaling pathways including T-cell activation, resulted in the identification of Carabin, a member of the TBC1 domain family of proteins, as a calcineurin-binding protein. Unlike other members of the TBC1 domain protein family which are thought to have a role in regulating cell growth and differentiation, further experiments demonstrated that Carabin is part of a negative regulatory loop for the intracellular TCR signaling pathway as well as an inhibitor of the Ras signaling pathway, suggesting that Carabin may also mediate crosstalk between calcineurin and Ras. Carabin antibody does not recognize TBC1D10A or TBC1D10B. Carabin is known to exist in multiple isoforms.Synonyms: TBC1 domain family member 10C, TBC1D10C
    Gene ID
    374403
    NCBI Accession
    NP_940919
    UniProt
    Q8IV04
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