You are viewing an incomplete version of our website. Please click to reload the website as full version.

IKBKG antibody (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma) (AA 61-137)

Details for Product anti-IKBKG Antibody No. ABIN567773, Supplier: Login to see New
New
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms
nemo, fj33c07, wu:fj33c07, zgc:113492, MGC97885, IKBKG, IKBKG_1, IKBKG_2, CG16910, DmIKK-gamma, DmIKKgamma, Dmel\\CG16910, Dmikkgamma, IKK, IKK-gamma, IKK[[gamma]], IKKg, IKKgamma, KEY, Kenny, Key, dI ... show more
nemo, fj33c07, wu:fj33c07, zgc:113492, MGC97885, IKBKG, IKBKG_1, IKBKG_2, CG16910, DmIKK-gamma, DmIKKgamma, Dmel\\CG16910, Dmikkgamma, IKK, IKK-gamma, IKK[[gamma]], IKKg, IKKgamma, KEY, Kenny, Key, dIKK, dIKK-gamma, dmIKKgamma, AMCBX1, FIP-3, FIP3, Fip3p, IP, IP1, IP2, IPD2, NEMO, ZC2HC9, Nemo, 1110037D23Rik, AI848108, AI851264, AW124339, IKK[g] show less
Alternatives
Epitope
AA 61-137
(32), (30), (28), (18), (13), (12), (11), (9), (6), (5), (5), (5), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(263), (73), (60), (5), (4), (4), (2), (2), (2), (2), (2), (1), (1)
Host
Mouse
(222), (44), (3), (2), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
This IKBKG antibody is un-conjugated
(8), (7), (7), (5), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3)
Application
Western Blotting (WB)
(198), (104), (60), (46), (36), (33), (16), (4), (4), (3), (3), (1), (1)
Pubmed 2 references available
Supplier Login to see New
Catalog number from supplier Login to see New
Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Human recombinant GST-IKKG (a.a. 61-137).
Clone DA10-12
Isotype IgG1
Specificity This antibody reacts with IKKG (45 kDa) on Western blotting.
Purification Protein-A Agarose Chromatography of hybridoma supernatant.
Alternative Name NEMO / IKBKG (IKBKG Antibody Abstract)
Background The I-kB kinase complex (IKK) functions as a mediator of NF-kB activation in response to multiple stimuli by phosphorylating I-kB inhibitor proteins and causing their degradation. IKK contains two structurally related catalytic subunits termed IKKA and IKKB as well as a noncatalytic subunit called IKKG/NEMO. IKK is composed of a IKKG/NEMO homodimer bound together with either an IKKA/IKKB heterodimer or an IKKB homodimer. Although IKKG /NEMO itself does not have kinase activity, it is essential for NF-kB activation likely via a scaffold function that is required for IKK activity. Mutations in the X-linked gene encoding IKKG can interfere with NF-kB signaling and lead to immunodeficiency disease.Synonyms: FIP-3, FIP3, I-kappa-B kinase subunit gamma, IKK-gamma, IKKAP1, IKKG, IkB kinase subunit gamma, IkB kinase-associated protein 1, Inhibitor of nuclear factor kappa-B kinase subunit gamma, NF-kappa-B essential modifier, NF-kappa-B essential modulator
Gene ID 8517
NCBI Accession NP_001093326
UniProt Q9Y6K9
Pathways NF-kappaB Signaling, RTK Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS, pH 7.2 containing 50 % Glycerol without preservatives.
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C.
Supplier Images
Western Blotting (WB) image for anti-IKBKG antibody (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma) (AA 61-137) (ABIN567773) anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (AA 61-137) antibody
Background publications Iha, Kibler, Yedavalli et al.: "Segregation of NF-kappaB activation through NEMO/IKKgamma by Tax and TNFalpha: implications for stimulus-specific interruption of oncogenic signaling." in: Oncogene, Vol. 22, Issue 55, pp. 8912-23, 2003 (PubMed).

Chu, Shin, Yang et al.: "IKKgamma mediates the interaction of cellular IkappaB kinases with the tax transforming protein of human T cell leukemia virus type 1." in: The Journal of biological chemistry, Vol. 274, Issue 22, pp. 15297-300, 1999 (PubMed).

Catalog No. ABIN567773
$346.50
Plus shipping costs $45.00

Order hotline:

  • +1 877 302 8632
  • +1 888 205 9894 (TF)