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Details for Product No. ABIN567773

Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (AA 61-137) antibody

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Antigen
Synonyms
AMCBX1, FIP-3, FIP3, Fip3p, IKK-gamma, IP, IP1, IP2, IPD2, NEMO, ZC2HC9, IKK[g], AI848108, AI851264, AW124339, 1110037D23Rik, Nemo, nemo, fj33c07, wu:fj33c07, zgc:113492, MGC97885, IKBKG, IKBKG_1, IKB ... show more
Epitope
»Alternatives AA 61-137
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN567773
Quantity 0.1 mg
Price
478.50 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 6 to 8 Business Days
Immunogen Human recombinant GST-IKKG (a.a. 61-137).
Clone DA10-12
Isotype IgG1
Specificity This antibody reacts with IKKG (45 kDa) on Western blotting.
Purification Protein-A Agarose Chromatography of hybridoma supernatant.
Alternative Name NEMO / IKBKG
Background The I-kB kinase complex (IKK) functions as a mediator of NF-kB activation in response to multiple stimuli by phosphorylating I-kB inhibitor proteins and causing their degradation. IKK contains two structurally related catalytic subunits termed IKKA and IKKB as well as a noncatalytic subunit called IKKG/NEMO. IKK is composed of a IKKG/NEMO homodimer bound together with either an IKKA/IKKB heterodimer or an IKKB homodimer. Although IKKG /NEMO itself does not have kinase activity, it is essential for NF-kB activation likely via a scaffold function that is required for IKK activity. Mutations in the X-linked gene encoding IKKG can interfere with NF-kB signaling and lead to immunodeficiency disease.
Alternate names: FIP-3, FIP3, I-kappa-B kinase subunit gamma, IKK-gamma, IKKAP1, IKKG, IkB kinase subunit gamma, IkB kinase-associated protein 1, Inhibitor of nuclear factor kappa-B kinase subunit gamma, NF-kappa-B essential modifier, NF-kappa-B essential modulator
Gene ID 8517
NCBI Accession NP_001093326
UniProt Q9Y6K9
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS, pH 7.2 containing 50% Glycerol without preservatives.
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20°C.
Expiry Date 12 months
Background publications Chu, Shin, Yang et al.: "IKKgamma mediates the interaction of cellular IkappaB kinases with the tax transforming protein of human T cell leukemia virus type 1." in: The Journal of biological chemistry, Vol. 274, Issue 22, pp. 15297-300, 1999 (PubMed).

Iha, Kibler, Yedavalli et al.: "Segregation of NF-kappaB activation through NEMO/IKKgamma by Tax and TNFalpha: implications for stimulus-specific interruption of oncogenic signaling." in: Oncogene, Vol. 22, Issue 55, pp. 8912-23, 2003 (PubMed).

Alternatives for antigen "Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG)", type "Antibodies"
Hosts (163), (27), (1)
Reactivities (188), (48), (44), (25), (14), (2), (2)
Applications (136), (82), (50), (45), (24), (20), (13), (3), (2), (1), (1)
Conjugates (6), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5)
Epitopes (21), (17), (17), (12), (11), (8), (5), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
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