CD80 (CD80) antibody

Details for Product No. ABIN567985
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Antigen
Synonyms CD8, Leu2, MAL, p32, B71, Cd28l, Ly-53, Ly53, MIC17, TSA1, B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7
Reactivity
Dog (Canine), Mouse (Murine)
(212), (167), (32), (13), (4), (4), (2), (1)
Host
Hamster
(178), (82), (75), (51), (12), (7)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(45), (43), (40), (14), (6), (5), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func), Immunoprecipitation (IP), Flow Cytometry (FACS)
(256), (107), (76), (56), (32), (31), (30), (24), (24), (22), (20), (2), (2), (1), (1), (1), (1), (1), (1)
Pubmed 9 references available
Quantity 0.1 mg
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Catalog No. ABIN567985
253.00 $
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Immunogen CD80-transfected CHO cell line
Clone 16-10A1
Isotype IgG2
Specificity This Hamster antibody reacts with CD80 (B7-1), a 60 kDa single chain type I glycoprotein of immunoglobulin supergene family, expressed on professional antigen-presenting cells, such as dendritic cells, macrophages or activated B lymphocytes.
Purification Protein-A affinity chromatography
Alternative Name CD80
Background CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28 and of an inhibitory receptor CTLA-4 (CD152). The both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, the both molecules can also substitute for each other in this process. The question what are the differences in CD80 and CD86 competency has not been fully elucidated yet, there are still conflicts in results about their respective roles in initiation or sustaining of the T cell immune response.
Alternate names: Activation B7-1 antigen, B7-1, B7.1, BB1, CD28LG, CD28LG1, CTLA-4 counter-receptor B7.1, LAB7, T-lymphocyte activation antigen CD80
Gene ID 12519
NCBI Accession NP_033985
UniProt Q00609
Research Area Stem Cells, Hematopoietic Progenitors, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline (PBS), pH~7.4 with 15 mM Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2-8°C for up to one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Horspool, Perrin, Woodcock et al.: "Nucleic acid vaccine-induced immune responses require CD28 costimulation and are regulated by CTLA4." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 6, pp. 2706-14, 1998 (PubMed).

Mencacci, Montagnoli, Bacci et al.: "CD80+Gr-1+ myeloid cells inhibit development of antifungal Th1 immunity in mice with candidiasis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 6, pp. 3180-90, 2002 (PubMed).

Gueirard, Ave, Balazuc et al.: "Bordetella bronchiseptica persists in the nasal cavities of mice and triggers early delivery of dendritic cells in the lymph nodes draining the lower and upper respiratory tract." in: Infection and immunity, Vol. 71, Issue 7, pp. 4137-43, 2003 (PubMed).

Quah, Ni, ONeill: "In vitro hematopoiesis produces a distinct class of immature dendritic cells from spleen progenitors with limited T cell stimulation capacity." in: International immunology, Vol. 16, Issue 4, pp. 567-77, 2004 (PubMed).

Reiser, von Gersdorff, Loos et al.: "Induction of B7-1 in podocytes is associated with nephrotic syndrome." in: The Journal of clinical investigation, Vol. 113, Issue 10, pp. 1390-7, 2004 (PubMed).

Paust, Lu, McCarty et al.: "Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 28, pp. 10398-403, 2004 (PubMed).

Odobasic, Kitching, Semple et al.: "Glomerular expression of CD80 and CD86 is required for leukocyte accumulation and injury in crescentic glomerulonephritis." in: Journal of the American Society of Nephrology : JASN, Vol. 16, Issue 7, pp. 2012-22, 2005 (PubMed).

Mukherjee, Ahmed, Malu et al.: "Modulation of cell cycle progression by CTLA4-CD80/CD86 interactions on CD4+ T cells depends on strength of the CD3 signal: critical role for IL-2." in: Journal of leukocyte biology, Vol. 80, Issue 1, pp. 66-74, 2006 (PubMed).

Ghann, Aras, Fleiter et al.: "Syntheses and characterization of lisinopril-coated gold nanoparticles as highly stable targeted CT contrast agents in cardiovascular diseases." in: Langmuir : the ACS journal of surfaces and colloids, Vol. 28, Issue 28, pp. 10398-408, 2012 (PubMed).

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