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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
CD14 Molecule (CD14) antibody
Alternatives Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB), ELISA, Functional Studies (Func)
|9 references available|
|Price||290.40 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 4 to 5 Business Days|
|Immunogen||A crude mixture of human urinary proteins precipitated by ammonium sulphate from the urine of a patient suffering from proteinuria.|
|Endotoxin Level||low endotoxin|
|Specificity||The antibody MEM-18 reacts with CD14, a 53-55 kDa GPI (glycosylphosphatidylinositol)-linked membrane glycoprotein expressed on monocytes, macrophages, weakly on granulocytes, also expressed by most tissue macrophages. In human, the epitope recognized by MEM-18 is located between amino acids 57-64. HLDA III, WS Code M 253, HLDA IV, WS Code M 314, HLDA V, WS Code M MA087, HLDA VI, WS Code M MA95|
|Buffer||Azide free phosphate buffered saline (PBS), approx. pH 7.4, 0.2 micrometer filter sterilized. Endotoxin level is less than 10 EU/mg of the protein, as determined by the LAL test.|
|Preservative (Components)||Azide free|
|Storage||Store at 2-8°C. Do not use after expiration date stamped on vial label. For long-term storage aliquot, store at -20°C. Avoid freeze/thaw cycles.|
|Research Area||CD Antigens|
|Restrictions||For Research Use only|
Bazil, Baudys, Hilgert et al.: "Structural relationship between the soluble and membrane-bound forms of human monocyte surface glycoprotein CD14." in: Molecular immunology, Vol. 26, Issue 7, pp. 657-62, 1989 (PubMed).
Bazil, Horejsí, Baudys et al.: "Biochemical characterization of a soluble form of the 53-kDa monocyte surface antigen." in: European journal of immunology, Vol. 16, Issue 12, pp. 1583-9, 1987 (PubMed).
Funda, Tucková, Farré et al.: "CD14 is expressed and released as soluble CD14 by human intestinal epithelial cells in vitro: lipopolysaccharide activation of epithelial cells revisited." in: Infection and immunity, Vol. 69, Issue 6, pp. 3772-81, 2001 (PubMed).
Stöckl, Majdic, Fischer et al.: "Monomorphic molecules function as additional recognition structures on haptenated target cells for HLA-A1-restricted, hapten-specific CTL." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 5, pp. 2724-33, 2001 (PubMed).
Sing, Rost, Tvardovskaia et al.: "Yersinia V-antigen exploits toll-like receptor 2 and CD14 for interleukin 10-mediated immunosuppression." in: The Journal of experimental medicine, Vol. 196, Issue 8, pp. 1017-24, 2002 (PubMed).
Iwaki, Nishitani, Mitsuzawa et al.: "The CD14 region spanning amino acids 57-64 is critical for interaction with the extracellular Toll-like receptor 2 domain." in: Biochemical and biophysical research communications, Vol. 328, Issue 1, pp. 173-6, 2005 (PubMed).
Drbal, Moertelmaier, Holzhauser et al.: "Single-molecule microscopy reveals heterogeneous dynamics of lipid raft components upon TCR engagement." in: International immunology, Vol. 19, Issue 5, pp. 675-84, 2007 (PubMed).
Angel, Lala, Chen et al.: "CD14+ antigen-presenting cells in human dermis are less mature than their CD1a+ counterparts." in: International immunology, Vol. 19, Issue 11, pp. 1271-9, 2007 (PubMed).
Weiss, Lichtenauer, Kirchner et al.: "Hepatic progenitor cells from adult human livers for cell transplantation." in: Gut, Vol. 57, Issue 8, pp. 1129-38, 2008 (PubMed).