Lysosomal-Associated Membrane Protein 1 (LAMP1) antibody

Details for Product No. ABIN638445
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Antigen
Synonyms AI196048, CD107a, Lamp-1, LAMPA, LGP120, LEP100
Reactivity
Human, Non-Human Primate, Mouse (Murine)
(149), (67), (58), (7), (7), (3), (2), (2)
Host
Mouse
(97), (85), (31), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(26), (18), (15), (10), (3), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Western Blotting (WB)
(118), (95), (46), (44), (41), (41), (30), (25), (18), (10), (1), (1)
Pubmed 8 references available
Quantity 0.1 mg
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Catalog No. ABIN638445
290.40 $
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Immunogen Human PBMC
Clone H4A3
Isotype IgG1
Specificity The mouse monoclonal antibody H4A3 recognizes CD107a, an approximately 100-120 kDa glycoprotein expressed mainly on lysosomal, but also on the plasma membrane.
Purification Purified from cell culture supernatant by protein-A affinity chromatography.
Purity > 95 % (by SDS-PAGE)
Sterility 0.2 μm filtered
Alternative Name LAMP1
Background CD107a (lysosome-associated membrane protein-1, LAMP-1), together with LAMP-2, is a major constituent of lysosomal membrane, 1-2 % of total CD107a is found also on the plasma membrane. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes. Increased CD107a immunoreactivity is observed in neurones, and in glial cells surrounding senile plaques in Alzheimers disease cases and is localized mainly in medullary epithelial cells, single macrophages and lymphocytes in acute thymic involution. CD107a is a good marker of mast cell activation.
Gene ID 3916
Research Area Cancer, Hematopoietic Progenitors, Organelles
Application Notes Western Blotting: Recommended dilution: 1 µg/mL

Working concentrations should be determined by the investigator.
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Azide free phosphate buffered saline (PBS), approx. pH 7.4.
Preservative Azide free
Handling Advice Do not freeze.
Storage 4 °C
Storage Comment Store at 2-8 °C. Do not use after expiration date stamped on vial label.
Product cited in: Mane, Marzella, Bainton et al.: "Purification and characterization of human lysosomal membrane glycoproteins." in: Archives of biochemistry and biophysics, Vol. 268, Issue 1, pp. 360-78, 1989 (PubMed).

Furuta, Ikeda, Nakayama et al.: "Expression of lysosome-associated membrane proteins in human colorectal neoplasms and inflammatory diseases." in: The American journal of pathology, Vol. 159, Issue 2, pp. 449-55, 2001 (PubMed).

Marcenaro, Gallo, Martini et al.: "Analysis of natural killer-cell function in familial hemophagocytic lymphohistiocytosis (FHL): defective CD107a surface expression heralds Munc13-4 defect and discriminates between genetic subtypes of the disease." in: Blood, Vol. 108, Issue 7, pp. 2316-23, 2006 (PubMed).

Deetz, Hebbeler, Propp et al.: "Gamma interferon secretion by human Vgamma2Vdelta2 T cells after stimulation with antibody against the T-cell receptor plus the Toll-Like receptor 2 agonist Pam3Cys." in: Infection and immunity, Vol. 74, Issue 8, pp. 4505-11, 2006 (PubMed).

Carlsten, Björkström, Norell et al.: "DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells." in: Cancer research, Vol. 67, Issue 3, pp. 1317-25, 2007 (PubMed).

Tomescu, Chehimi, Maino et al.: "NK cell lysis of HIV-1-infected autologous CD4 primary T cells: requirement for IFN-mediated NK activation by plasmacytoid dendritic cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 4, pp. 2097-104, 2007 (PubMed).

Yu, Gallegos, Marches et al.: "Broad influenza-specific CD8+ T-cell responses in humanized mice vaccinated with influenza virus vaccines." in: Blood, Vol. 112, Issue 9, pp. 3671-8, 2008 (PubMed).

Mao, Tu, Liu et al.: "Inhibition of human natural killer cell activity by influenza virions and hemagglutinin." in: Journal of virology, Vol. 84, Issue 9, pp. 4148-57, 2010 (PubMed).

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