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Details for Product No. ABIN650724

Growth Arrest and DNA-Damage-Inducible, alpha (GADD45A) (C-Term), (AA 133-165) antibody

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Synonyms DDIT1, GADD45, Ddit1, Gadd45, AA545191, MGC53491, gadd45a, zgc:91795, GADD45A, ddit1, gadd45
»Alternatives C-Term, AA 133-165
»Alternatives Human
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB), Flow Cytometry (FACS)
Pubmed 4 references available
Catalog no. ABIN650724
Quantity 400 µL
291.50 $   Plus shipping costs $45.00
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Immunogen This GADD45A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 133-165 AA from the C-terminal region of human GADD45A.
Clone RB16521
Isotype Ig
Specificity This GADD45A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136~165 amino acids from the C-terminal region of human GADD45A.
Predicted Reactivity Cow (Bovine),Hamster,Mouse (Murine),Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name GADD45A
Background GADD45A responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45A gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms.
Synonyms: Growth arrest and DNA-damage-inducible protein GADD45 alpha, DNA-damage-inducible transcript 1, DDIT-1, GADD45A, DDIT1, GADD45
Molecular Weight 18205 DA
Gene ID 1647
UniProt P24522
Research Area Stem Cells, Protein Modifications
Application Notes Recommend dilutions: WB : 1:1000,FC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Kearsey, Coates, Prescott et al.: "Gadd45 is a nuclear cell cycle regulated protein which interacts with p21Cip1." in: Oncogene, Vol. 11, Issue 9, pp. 1675-83, 1995 (PubMed).

Zhu, Ren, Korchin et al.: "Soft tissue sarcoma cells are highly sensitive to AKT blockade: a role for p53-independent up-regulation of GADD45 alpha." in: Cancer research, Vol. 68, Issue 8, pp. 2895-903, 2008 (PubMed).

Al-Romaih, Sadikovic, Yoshimoto et al.: "Decitabine-induced demethylation of 5' CpG island in GADD45A leads to apoptosis in osteosarcoma cells." in: Neoplasia (New York, N.Y.), Vol. 10, Issue 5, pp. 471-80, 2008 (PubMed).

Li, Morales, Hwang et al.: "DNA mismatch repair-dependent activation of c-Abl/p73alpha/GADD45alpha-mediated apoptosis." in: The Journal of biological chemistry, Vol. 283, Issue 31, pp. 21394-403, 2008 (PubMed).

Alternatives for antigen "Growth Arrest and DNA-Damage-Inducible, alpha (GADD45A)", type "Antibodies"
Hosts (32), (6)
Reactivities (38), (16), (15), (12), (12), (12)
Applications (26), (11), (10), (5), (4), (3), (2), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (6), (5), (3), (2), (1), (1), (1)