Xeroderma Pigmentosum, Complementation Group A (XPA) (C-Term), (AA 221-250) antibody

Details for Product No. ABIN652730
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Antigen
Epitope
C-Term, AA 221-250
(19), (7), (5), (3), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(66), (19), (5)
Host
Rabbit
(50), (17)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
(65), (27), (21), (16), (10), (6), (5), (3), (1), (1)
Pubmed 1 reference available
Quantity 400 µL
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Catalog No. ABIN652730
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Immunogen This XPA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 221-250 AA from the C-terminal region of human XPA.
Clone RB23644
Isotype Ig
Specificity This XPA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 228~258 amino acids from the C-term region of human XPA .
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name XPA
Background XPA is involved in DNA excision repair. It initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. This protein is required for UV-induced CHK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.
Synonyms: Xeroderma pigmentosum group A-complementing protein, DNA repair protein complementing XP-A cells, XPA, XPAC
Molecular Weight 31368 DA
Gene ID 7507
UniProt P23025
Research Area Signaling, Neurology
Application Notes WB = 1:1000, IHC = 1:50-100, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Xeroderma Pigmentosum, Complementation Group A (XPA) (C-Term), (AA 221-250) antibody Western blot analysis of XPA Antibody (C-term) (ABIN652730) in NCI-H460 cell line lysates (35 µg/lane). XPA (arrow) was detected using the purified polyclonal antibody.
anti-Xeroderma Pigmentosum, Complementation Group A (XPA) (C-Term), (AA 221-250) antibody (2) Formalin-fixed and paraffin-embedded human lung carcinoma reacted with XPA Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
anti-Xeroderma Pigmentosum, Complementation Group A (XPA) (C-Term), (AA 221-250) antibody (3) XPA Antibody (C-term) (ABIN652730) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Background publications States, McDuffie, Myrand et al.: "Distribution of mutations in the human xeroderma pigmentosum group A gene and their relationships to the functional regions of the DNA damage recognition protein." in: Human mutation, Vol. 12, Issue 2, pp. 103-13, 1998 (PubMed).

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