Hepcidin Antimicrobial Peptide (HAMP) (AA 17-46), (Center) antibody

Details for Product No. ABIN653413
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Antigen
Epitope
AA 17-46, Center
(11), (10), (8), (7), (5), (4), (2), (2), (1), (1), (1), (1)
Reactivity
Human
(53), (12), (1), (1), (1)
Host
Rabbit
(48), (10), (5)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(5), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(56), (48), (19), (12), (7), (6), (3), (2), (2), (2), (1)
Pubmed 1 reference available
Quantity 400 μL
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Catalog No. ABIN653413
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Immunogen This HAMP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-46 AA from the Central region of human HAMP.
Clone RB22098
Isotype Ig
Specificity This HAMP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24~54 amino acids from the Central region of human HAMP.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name HAMP
Background HAMP is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity.
Synonyms: Hepcidin-20, Hepc20, Hepcidin-25, Hepc25, Putative liver tumor regressor, PLTR, Liver-expressed antimicrobial peptide 1, LEAP-1, Hepcidin, UNQ487/PRO1003, LEAP1, HEPC, HAMP
Molecular Weight 9408 DA
Gene ID 57817
UniProt P81172
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.3 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Hepcidin Antimicrobial Peptide (HAMP) (AA 17-46), (Center) antibody Western blot analysis of HAMP Antibody (Center) (ABIN653413) in MDA-MB435 cell line lysates (35 µg/lane). HAMP (arrow) was detected using the purified polyclonal antibody.
Background publications Hunter, Fulton, Ganz et al.: "The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis." in: The Journal of biological chemistry, Vol. 277, Issue 40, pp. 37597-603, 2002 (PubMed).

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