Hepcidin antibody (AA 25-85)

Catalog No. ABIN614727

Product Details anti-Hepcidin Antibody

Target: Hepcidin (HAMP) (Hepcidin Antimicrobial Peptide (HAMP))

Binding Specificity: AA 25-85

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Hepcidin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to Hepcidin Antimicrobial Peptide (HAMP).

Purification: Protein A Chromatography

Immunogen: Recombinant protein, HAMP (AAH20612, 25 a.a. ~ 85 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Genename: HAMP

Clone: 1F9

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS, pH 7.2

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Target Details for Hepcidin

Target: Hepcidin (HAMP) (Hepcidin Antimicrobial Peptide (HAMP))

Alternative Name: Hepcidin / HAMP (HAMP Products)

Synonyms: HEPC antibody, HFE2B antibody, LEAP1 antibody, PLTR antibody, Hepcidin antibody, Hamp1 antibody, Hepc antibody, Hepc1 antibody, HAMP antibody, hepcidin antibody, hamp1 antibody, hep1 antibody, hepcidin antimicrobial peptide antibody, hepcidin-like antibody, hepcidin-1 antibody, Ham percentage antibody, HAMP antibody, Hamp antibody, hamp antibody, LOC100135935 antibody, LOC106584587 antibody

Background: Hepcidin, an human antimicrobial peptide, contains a leader sequence, a proteolysis site and a C-terminal 25 amino acid active peptide. This peptide is most active against gram-positive bacteria, but also inhibits the growth of certain yeast and gram-negative bacteria. HAMP also functions as a signaling molecule involved in the maintenance of iron homeostasis. In conjugation with HFE it seems to regulate both intestinal iron absorption and iron storage in macrophages. Mutations in HAMP are found in juvenile hemochromatosis.Synonyms: HEPC, LEAP-1, LEAP1, Liver-expressed antimicrobial peptide, PLTR, Putative liver tumor regressor

Gene ID: 57817

NCBI Accession: NP_066998

UniProt: P81172

Pathways: Hormone Activity, Transition Metal Ion Homeostasis