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Endonuclease VIII-Like 1 (NEIL1) (AA 130-159), (Center) antibody

Details for Product No. ABIN653649
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Antigen
Epitope
AA 130-159, Center
(10), (3), (2), (1), (1), (1), (1)
Reactivity
Human
(29), (2), (2), (1), (1)
Host
Rabbit
(20), (7), (2)
Clonality (Clone)
Polyclonal ()
Application
Western Blotting (WB)
(23), (18), (4), (3), (1)
Pubmed 3 references available
Quantity 400 µL
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Catalog No. ABIN653649
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Immunogen This NEIL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 130-159 AA from the Central region of human NEIL1.
Clone RB18510
Isotype Ig
Specificity This NEIL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 137~167 amino acids from the Central region of human NEIL1.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name NEIL1
Background NEIL1 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).
Synonyms: FPG1, Nei homolog 1, NEH1, Nei-like protein 1, DNA-(apurinic or apyrimidinic site) lyase Neil1, DNA glycosylase/AP lyase Neil1, Endonuclease VIII-like 1, NEIL1
Molecular Weight 43684 DA
Gene ID 79661
UniProt Q96FI4
Research Area Cancer, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Endonuclease VIII-Like 1 (NEIL1) (AA 130-159), (Center) antibody Western blot analysis of NEIL1 Antibody (Center) (ABIN653649) in A2058 cell line lysates (35 µg/lane). NEIL1 (arrow) was detected using the purified polyclonal antibody.
Background publications Horikawa, Wood, Yang et al.: "Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 14, Issue 23, pp. 7956-62, 2008 (PubMed).

Muftuoglu, de Souza-Pinto, Dogan et al.: "Cockayne syndrome group B protein stimulates repair of formamidopyrimidines by NEIL1 DNA glycosylase." in: The Journal of biological chemistry, Vol. 284, Issue 14, pp. 9270-9, 2009 (PubMed).

Zhao, Krishnamurthy, Burrows et al.: "Mutation versus repair: NEIL1 removal of hydantoin lesions in single-stranded, bulge, bubble, and duplex DNA contexts." in: Biochemistry, Vol. 49, Issue 8, pp. 1658-66, 2010 (PubMed).

Validation Images
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