NEIL1 antibody

Catalog No. ABIN7073820

The Rabbit Polyclonal anti-NEIL1 antibody is suitable to detect NEIL1 in samples from Human, Rat and Mouse. It has been validated for WB, IHC and IF.

Quick Overview for NEIL1 antibody (ABIN7073820)

Target: NEIL1 (Endonuclease VIII-Like 1 (NEIL1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NEIL1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-NEIL1 Antibody

Cross-Reactivity: Human, Rat

Purification: Affinity purification

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse NEIL1

Application Details

Application Notes: WB (M,R) 1:800-1:1600, IHC/IF (H,M,R) 1:1200-1:3000/1:300-1:600

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for NEIL1

Target: NEIL1 (Endonuclease VIII-Like 1 (NEIL1))

Alternative Name: NEIL1

Background: NEIL1, also named as NEH1 and FPG1, belongs to the FPG family. It is involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. NEIL1 acts as DNA glycosylase that recognizes and removes damaged bases. It has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. NEIL1 has marginal activity towards 8-oxoguanine. It has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.

Molecular Weight: 44 kDa

Gene ID: 72774

NCBI Accession: NP_082623

UniProt: Q8K4Q6

Pathways: DNA Damage Repair