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ATPase, H+ Transporting, Lysosomal 70kDa, V1 Subunit A (ATP6V1A) (AA 441-468), (Center) antibody

Details for Product No. ABIN653735
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Antigen
Epitope
AA 441-468, Center
(8), (2), (2), (2), (1), (1)
Reactivity
Human
(36), (19), (16), (15), (13), (13), (3), (3), (2), (2), (2), (2), (1)
Host
Rabbit
(33), (5)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(28), (19), (11), (10), (9), (1), (1)
Pubmed 4 references available
Quantity 400 µL
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Catalog No. ABIN653735
291.50 $
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  • +1 404 474 4654
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Immunogen This ATP6V1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 441-468 AA from the Central region of human ATP6V1A.
Clone RB24578
Isotype Ig
Specificity This ATP6V1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 447~477 amino acids from the Central region of human ATP6V1A.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Pig (Porcine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ATP6V1A
Background This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues.
Synonyms: Vacuolar ATPase isoform VA68, V-ATPase 69 kDa subunit, Vacuolar proton pump subunit alpha, V-type proton ATPase catalytic subunit A, V-ATPase subunit A,VPP2, ATP6V1A1, ATP6A1, ATP6V1A
Molecular Weight 68304 DA
Gene ID 523
UniProt P38606
Research Area Cancer, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-ATPase, H+ Transporting, Lysosomal 70kDa, V1 Subunit A (ATP6V1A) (AA 441-468), (Center) antibody Western blot analysis of ATP6V1A Antibody (Center) (ABIN653735) in A2058 cell line lysates (35 µg/lane). ATP6V1A (arrow) was detected using the purified polyclonal antibody.
anti-ATPase, H+ Transporting, Lysosomal 70kDa, V1 Subunit A (ATP6V1A) (AA 441-468), (Center) antibody (2) ATP6V1A Antibody (Center) (ABIN653735) IHC analysis in formalin fixed and paraffin embedded breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining
Product cited in: Nabatov, Hatzis, Rouschop et al.: "Hypoxia inducible NOD2 interacts with 3-O-sulfogalactoceramide and regulates vesicular homeostasis." in: Biochimica et biophysica acta, 2013 (PubMed).

Background publications Morel: "Neurotransmitter release: the dark side of the vacuolar-H+ATPase." in: Biology of the cell / under the auspices of the European Cell Biology Organization, Vol. 95, Issue 7, pp. 453-7, 2003 (PubMed).

Ahmed, Forsberg, Bergsten: "Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry." in: Journal of proteome research, Vol. 4, Issue 3, pp. 931-40, 2005 (PubMed).

Martins-de-Souza, Gattaz, Schmitt et al.: "Proteomic analysis of dorsolateral prefrontal cortex indicates the involvement of cytoskeleton, oligodendrocyte, energy metabolism and new potential markers in schizophrenia." in: Journal of psychiatric research, Vol. 43, Issue 11, pp. 978-86, 2009 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN653735
291.50 $
Plus shipping costs $45.00
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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